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My low GABA levels - Interesting rabbit hole

Beyond

Juice Me Up, Scotty!!!
Messages
1,122
Location
Murcia, Spain
So I got tested once two years ago and I was awfully defficient in GABA. Probably the most severe defficiency I have ever showed in tests.

http://www.vitalityandwellness.com.au/low-gaba-levels

I have already posted this, but, no harm in posting it here again for those that didn´t saw it!
http://www.cortjohnson.org/blog/201...fs-puzzle-the-neuroinflammatory-series-pt-ii/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579978/

Is interesting to note it decreases digestive enzyme production (!). I also was very defficient in Taurine, the symbiotic aminoacid of GABA and needed for it to work properly.

I have also high prolactin, which is lowered by GABA (low, checked) and DHEA (low, checked). And chronic pain related to tense muscles. Lastly I have low glutamic acid and B6 levels and plenty of GAD1 mutations.
GABA is formed through the activity of the enzyme glutamic acid decarboxylase (GAD). GAD catalyzes the formation of GABA from glutamic acid. The synthesis of GABA is linked to the Kreb's cycle. GAD requires vitamin B6 (pyridoxal phosphate) as a cofactor, which can be used to regulate the levels of GABA. Vitamin B6 is a key GABA vitamin.
http://www.integrativepsychiatry.net/natural_gaba.html

So I am very eager to eat these PharmaGABA pills...
 
Last edited:

NotThisGuy

Senior Member
Messages
312
So I got tested once two years ago and I was awfully defficient in GABA. Probably the most severe defficiency I have ever showed in tests.

http://www.vitalityandwellness.com.au/low-gaba-levels

I have already posted this, but, no harm in posting it here again for those that didn´t saw it!
http://www.cortjohnson.org/blog/201...fs-puzzle-the-neuroinflammatory-series-pt-ii/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579978/

Is interesting to note it decreases digestive enzyme production (!). I also was very defficient in Taurine, the symbiotic aminoacid of GABA and needed for it to work properly.

I have also high prolactin, which is lowered by GABA (low, checked) and DHEA (low, checked). And chronic pain related to tense muscles. Lastly I have low glutamic acid and B6 levels and plenty of GAD1 mutations.

http://www.integrativepsychiatry.net/natural_gaba.html

So I am very eager to eat these PharmaGABA pills...

Have u tried to supplement glutamic acid with b6 in the meanwhile?
I stopped tolerating B6 (dont know why).
But maybe my low glutamic acid is why B6 stopped working.
 

Gingergrrl

Senior Member
Messages
16,171
So I got tested once two years ago and I was awfully defficient in GABA. Probably the most severe defficiency I have ever showed in tests.

@Beyond Have you ever been tested to see if you have the autoantibody against GAD65? I have this and it attacks the enzyme that allows glutamate to convert to GABA. Prior to getting IVIG, I was tortured by an insane startle reflex to every day noises and possibly had one "startle seizure" to the fire alarm although we are not certain. After IVIG, the startle reflex has disappeared and never returned. It might be worth getting tested for. GAD65 often links to diabetes but in my case, it did not.