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Muscles pain, weakness, cramps. Diamox vs Mestinon

Discussion in 'General Treatment' started by pattismith, Dec 10, 2017.

  1. pattismith

    pattismith Senior Member

    Diamox (acetazolamide) , and other carboxic anhydride inhibitors , are diuretics which si used to treat HPP (hypokalemia periodic paralysis). This disease is a genetic muscle channelopathy.

    Mestinon (pyridostigmine) and other cholinesterase inhibitors are used to treat MG (myasthenia gravis), an auto-immune disease.

    Both diseases induce muscle weakness and are sensitive to low blood potassium, but two interesting things can help to diferenciate, apart from specific diagnostic tests:

    Diamox can worsen MG
    Mestinon cannot help HPP and can worsen it

    I have tryed both Mestinon-like drug and Diamox and after a few days I can say only Diamox helps me.
    One interesting thing I noticed is that almost immediatly I was able to walk better and that my hips better fit in their socket (much less "cloc " when moving), so obviously my muscle strenght improved. I don't think that I have HPP, but impairment of some ion-channel yes.

    I may have this problem for a long time but it was dramatically worsen by the long antibiotic treatment I had with azythromycin and Doxycycline, this is why I wanted to share my finding and experimentation.
    Last edited: Dec 11, 2017
    Mel9, crypt0cu1t, sb4 and 5 others like this.
  2. crypt0cu1t

    crypt0cu1t IG: @skagginwagon

    What if i have both MG AND HPP
  3. pattismith

    pattismith Senior Member

    dit you try Mestinon, and did you try Diamox?

    is your blood potassium level low?

    i have found the main root of my muscle affection: the low T3 syndrome;

    My fT3 is in the normal range but close to the minimum, and my rT3 is up, which can block some non nuclear T3 effect (calcium and potassium fluxes are affected, which can produce many symptoms);

    I also found that adrenal hormons have an impact of these fluxes, so I may have a complexe issue with more than a lack of T3.
    sb4 and Learner1 like this.
  4. Mel9

    Mel9 Senior Member

    NSW Australia
    Mestinon has completely stopped my POTS, fatigue and PEM, but these return if I don’t have my 30mg every 6 hours.

    I don’t think I have MG but how would I know?
    voner and sb4 like this.
  5. Shoshana

    Shoshana Northern USA

    Northern USA
    There is a simple blood test @Mel9 but I have no idea how accurate it is or is not. It might need multiple ways to dx it for certain.

    I am glad to hear that med is helping you, in any case!
    Mel9 likes this.
  6. voner

    voner Senior Member

    Mel9 and pattismith like this.

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