International ME/CFS and FM Awareness Day Is On May 12, 2018
Thomas Hennessy, Jr., selected May 12th to be our international awareness day back in 1992. He knew that May 12th had also been the birthday of Florence Nightingale. She was the English army nurse who helped to found the Red Cross as well as the first school of nursing in the world.
Discuss the article on the Forums.

MTHFRSupport Variant Report,geneticgenie, and NutraHacker need help to begin

Discussion in 'Genetic Testing and SNPs' started by joelle1059, May 25, 2015.

  1. joelle1059


    Hi everyone,
    I received the report , read a lot information, but i m very confused and really do not know how to begin, i would appreciate some help thank you

    ACAT1 rs3741049 A AG +/-
    ACE rs4343 G AG +/-
    AGT rs699 A AA +/+
    AHCY-01 rs819147 C CC +/+

    AHCY-19 rs819171 C CC +/+
    BHMT rs3733890 A GG -/-
    BHMT-02 rs567754 T TT +/+
    BHMT-08 rs651852 T TT +/+
    C1orf167 rs4846048 G AA -/-
    CBS rs2851391 T CT +/-
    CBS rs4920037 A GG -/-
    CBS A360A rs1801181 A GG -/-
    CBS C699T rs234706 A AG +/-
    CBS N212N rs2298758 A __ NG
    CLCN6 rs13306560 T CC -/-
    CLCN6 rs13306561 G __ NG

    COMT rs6269 G AA -/-
    COMT H62H rs4633 T TT +/+
    COMT P199P rs769224 A AG +/-
    COMT V158M rs4680 A AA +/+
    DAO rs2070586 A GG -/-
    DAO rs3741775 C AC +/-

    DHFR rs1643649 C CT +/-
    FOLR1 rs2071010 A GG -/-
    FOLR2 rs651933 G AG +/-
    FOLR3 rs7925545 G AA -/-
    FUT2 rs492602 G GG +/+
    FUT2 rs601338 A AA +/+
    FUT2 rs602662 A AA +/+
    G6PD rs1050828 - CC
    G6PD rs1050829 - TT
    GAD1 rs10432420 A AG +/-
    GAD1 rs12185692 A AC +/-
    GAD1 rs2058725 C CT +/-
    GAD1 rs2241165 C CT +/-
    GAD1 rs3749034 A AG +/-
    GAD1 rs3791850 A AG +/-
    GAD1 rs3791851 C TT -/-
    GAD1 rs3791878 T GG -/-
    GAD1 rs3828275 T CT +/-
    GAD1 rs701492 T CC -/-
    GAD1 rs769407 C GG -/-
    GAMT rs17851582 A GG -/-
    GAMT rs55776826 T CT +/-
    GIF rs558660 A AG +/-
    MAOA rs6323 - TT
    MAOB rs1799836 - CT
    MTHFD1 rs1076991 T CT +/-
    MTHFD1 rs2236225 A AG +/-
    MTHFD1L rs11754661 A GG -/-
    MTHFD1L rs17349743 C CT +/-
    MTHFD1L rs6922269 A GG -/-
    MTHFD1L rs803422 A AG +/-
    MTHFR rs12121543 - __
    MTHFR rs1476413 T CT +/-
    MTHFR rs17037390 A AG +/-
    MTHFR rs17367504 G AG +/-
    MTHFR rs2066470 A AG +/-
    MTHFR rs2274976 T CC -/-
    MTHFR rs4846049 T GT +/-
    MTHFR A1298C rs1801131 G GT +/-
    MTHFR C677T rs1801133 A AG +/-
    MTHFS rs6495446 T CC -/-
    MTR A2756G rs1805087 G AG +/-
    MTRR rs10380 T __ NG
    MTRR rs1801394 G AG +/-
    MTRR A664A rs1802059 A GG -/-
    MTRR K350A rs162036 G AA -/-
    NOS2 rs2248814 A GG -/-
    NOS2 rs2274894 T GG -/-
    NOS2 rs2297518 A GG -/-
    NOS3 rs1800779 G AG +/-
    NOS3 rs1800783 A AT +/-
    PEMT rs4244593 T GG -/-
    SOD2 rs2758331 A AC +/-
    SOD2 rs4880 G AG +/-
    SOD3 rs2855262 C TT -/-
    TCN1 rs526934 G AA -/-
    TCN2 rs1801198 G GG +/+
    VDR Bsm rs1544410 T CC -/-
    VDR Taq rs731236 G AA -/-
  2. pogoman

    pogoman Senior Member

    you are compound hetero for the mthfr mutations involving folate and homozygous for transcobalim2 that can lead to B12 absorbtion problems.
    you also have comt homozygous mutations but I am not sure of their importance.

    not knowing your symptoms I can suggest you try out a methylation treatment by taking methylfolate, methyl B12, hydroxy B12 and lithium orotate, start with low amounts at first to see how you react.
    I suggest the hydroxy B12 and lithium orotate to help with the tcn2 mutation.
    I have similar snp's to yours and this has helped immensely
  3. Valentijn

    Valentijn Senior Member

    That's just a possibility, unless the parents' mutations are also known. There's a 50/50 chance that it's not compound.
  4. ahmo

    ahmo Senior Member

    Northcoast NSW, Australia
    a good place to start is @caledonia signature line.,esp links to her snp guide, and then her many resources re how to begin methylation treatment.
    AndyPandy likes this.
  5. joelle1059


    thank you
  6. pogoman

    pogoman Senior Member

    Well, I figured if somebody went to the trouble of joining and posting here then they have medical issues of some sort ;)
    According to Stanford University's genetic page, getting a compound mthfr mutation from just one parent is rare and more likely to be from both parents.
    But I disagree with some of their assumptions so I post it for what its worth.
  7. Valentijn

    Valentijn Senior Member

    MTHFR C677T and/or A1298C aren't likely to be causing serious medical issues, aside from in the fetuses of those who have the mutations. And even then, those problems are corrected with a normal dose of folate or eating vegetables on a regular basis.

    And there are quite a few other ways which problems can be solved. MTHFR is not the end-all and the be-all.
    Stanford apparently funded the site to some extent, but has no involvement with the content. And I'm very wary of someone making a lot of claims without any citations at all ... frankly it turns the whole thing into yet another useless opinion piece which can not be verified.
  8. joelle1059


    I m in deed having health problem ,i suffered from extrem mood swing to depression in my early 20 to 40 for some reason i m more stable now, diabetic,hypothyroidism,fatigue .i was witness of several member of ny family including my mum having b12 deficiency .i m just begining to understand and all advice is more welcome
    I test at 12and me, than ran the genome at promethase,then the others thank you

    gs192MTHFR polymorphisms affecting homocysteine You have a combination of 2 SNP variations in MTHFR which influence homocysteine levels. This is found in ~20% of people. 0.08% of people had a double copy of a mutation in one of the SNPs, and a single mutation in the othe. *rs1801131 is at position 1298 *rs1801133 is at position 677 *
  9. caledonia


    Cincinnati, OH, USA
    Hi Joelle, I'm just popping in quickly so you can see my signature link. Follow that to the SNPs Interpretation Guide.

    With the reported moods swings and COMT mutations you're going to have to be cautious with B12 and methylfolate supplementation so you don't make mood swings worse. This doesn't mean you don't have a deficiency and that this supplementation won't be helpful. My documents will explain more.
  10. joelle1059


    Thank you Caledonia

  11. out2lunch

    out2lunch Senior Member

    You're homozygous for the three FUT2 genes like I am. I just recently learned that FUT2 SNPs are associated with intestinal dysbiosis involving bifidobacterium. Apparently folks like us have problems keeping enough of it in our guts and need to supplement it, big time:

    We also have a greater tendency to develop Crohn's disease and other G.I. autoimmune problems.

    But on the plus side, these mutations make us less likely to develop H. Pylori or norovirus infections. So the news isn't all bad. ;)

See more popular forum discussions.

Share This Page