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Montreal ME/CFS II: Stopping PEM, the Antibody Subset and Unutmaz’s Big Surprise

Discussion in 'Latest ME/CFS Research' started by Gingergrrl, Jun 1, 2018.

  1. Gingergrrl

    Gingergrrl Senior Member

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    I searched in case this link was already posted but couldn't find it. It is from Cort's blog /Simmaron Research re: the recent Montreal Conference. I am particularly interested in Dr. Scheibenbogen's autoantibody research so I am quoting some of that portion (but there is a lot more to read on other topics, too)!

    http://simmaronresearch.com/2018/05/montreal-ii-stopping-pem-antibody-subset-unutmazs-big-surprise/

     
    leokitten, bertiedog, Murph and 9 others like this.
  2. Diwi9

    Diwi9 Administrator

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    @Gingergrrl - Thank you, been waiting for Cort to post the second part of Montreal!
     
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  3. msf

    msf Senior Member

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    It's already possible to stop PEM, but high amounts of dca cause peripheral neuropathy, so hopefully they're coming up with a less problematic alternative.
     
  4. msf

    msf Senior Member

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    PEM caused by lactic acid build up, that is.
     
    Last edited: Jun 4, 2018
  5. lnester7

    lnester7 Seven

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    What is DCA? Never heard of it for PEM
     
  6. msf

    msf Senior Member

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    There's a whole thread and pilot study on it, just Google it. DCA stands for dichloroacetate. If you want to know how it might work, I wrote a blog about how I think ME works, and DCA fits nicely with that (once you know that it is also an mtor inhibitor).
     
    Last edited: Jun 5, 2018
  7. Murph

    Murph :)

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    Both part of @Cort's montreal write-up are worth a read.

    I'm interested in Unutmaz and his T-Cell work that finds a link to the gut certainly seems like it could be a missing link for us.

    I liked this from Keller too. Almost enough to make me want to get a two CPET ;)

     
  8. bertiedog

    bertiedog Senior Member

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    This seems to tie in with the description the Scientist was giving in her interview in the BBC Radio 4 recording today of Life Scientific which I posted earlier.

    I cannot believe that this won't pan out as to be a major issue for many of us with ME.

    Pam
     
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  9. msf

    msf Senior Member

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    Yeah, the t cell stuff is really interesting, and kdm et all have reported a t cell independent pathway that is altered in me patients too. The word activated suggests that the MAIT cells are also ramping up glycolysis, hence the effectiveness (I believe) of dca in ramping down the immune response.
     
    Last edited: Jun 5, 2018
  10. msf

    msf Senior Member

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    Oops, didn't mean to quote myself.
     

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