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MODY Diabetes

xks201

Senior Member
Messages
740
I wanted to bring something up that many of you may have underlooked. MODY is basically not type 1 or type 2. Certain genetic mutations passed on can cause this. My symptoms are insulin resistance to my own insulin (as seen on a glucose tolerance test), yet when I inject insulin I am extremely sensitive to it.

If you have insulin resistance but are skinny and not fat, it is a possibility. Apparently there are 9 known mutations, but probably more genes could contribute to it. I am going to experiment with fast acting insulin as insulin in general does seem to have a positive effect on me.
 

taniaaust1

Senior Member
Messages
13,054
Location
Sth Australia
Ive trying to get my head around "insulin resistance to insulin".. Im struggling to comprehend what you are trying to say. Sounds interesting thou.. im going to look it up .

for anyone wondering how the body usually develops insulin resistance.. a fairly easy explaination is at http://lowcarbdiets.about.com/od/prediabetesanddiabetes/a/insulinresistan.htm
Insulin resistance is a decreased ability of some of the cells of the body to respond to insulin.

It is the beginning of the body not dealing well with sugar (and remember that all carbohydrate breaks down into sugar in our bodies). One of insulin's main jobs is to get certain body cells to "open up" to take in glucose (or, more accurately to store the glucose as fat). Insulin resistance happens when the cells essentially don't open the door when insulin comes knocking. When this happens, the body puts out more insulin to stabilize blood glucose (and so the cells can use the glucose).

My symptoms are insulin resistance to my own insulin

Im confused at what you are saying, due to (as far as I know) EVERYONE with insulin resistance has this cellular resistance to their own insulin so hence insulin resistant to their own insulin.

I guess you must be a diabetic who also has insulin resistance seeing you are injecting it as one wouldnt inject it otherwise (I know one can be both diabetic and have insulin resistance too..which makes treatment more complicated). Is that the message you are trying to say.. 3 different types of diabetes? one in which includes insulin resistance?
 

taniaaust1

Senior Member
Messages
13,054
Location
Sth Australia
umm it is interesting.. as some of what Im reading about.. may be relevant to me. http://en.wikipedia.org/wiki/MODY_2
The beta cells in MODY 2 have a normal ability to make and secrete insulin, but do so only above an abnormally high threshold (e.g., 126–144 mg/dl, or 7-8 mM). This produces chronic, mild hyperglycemia which is usually asymptomatic. It is usually detected by accidental discovery of mild hyperglycemia (e.g., during pregnancy screening).

The degree of hyperglycemia does not worsen rapidly with age, and long-term diabetic complications are rare.

Going back 20 years ago when pregnant with my child.. I had hyperglycemia on my sugar test .. they did test again due to being concerned about it but it was okay the next time it was tested. I had some hyperglycemia too the time before last when I was in hospital and they had me on a glucose drip ( i couldnt eat).. their standard drip practice gave me hyperglycemia so they had to take me off of it.

Those are the only times it has been noted i had hyperglycemia.. as my high insulin often makes me have hypoglycemia. My own insulin makes me sick if I arent on a strict diet... I know many places dont say it but insulin can make some quite unwell (makes many of my ME symptoms worst).

2 of my specialists due to the hyperinsulinemia have said I will end up with diabetes.. so reading about this problem was reassuring to read that if i did have that.. im less likely to end up diabetic as it says it dont worsen with age