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ME/CFS, XMRV, DSM-V and the British Medical Journal - 6 March 2010

Discussion in 'Media, Interviews, Blogs, Talks, Events about XMRV' started by natasa778, Mar 4, 2010.

  1. natasa778

    natasa778 Senior Member

  2. Gerwyn

    Gerwyn Guest

    red alert

    how can this woman be a retrovirologist AND AN HONOURARY CONSULTANT IN GENITOURINARY MEDICINE

    THIS WOMAN IS A MEDIC.No scientiist after one study would say that XMRV has nothing to do with ME?CFS after one study but a doctor with a vested interest could and maybe would We need her background and association with Wesselly
  3. Gerwyn

    Gerwyn Guest

    I Think I,m wondering about collusion a doctor in london should know about the controversy re the diagnosis of the condition I am thinking out loud but when did she achieve honarary consultant status and how?
  4. Countrygirl

    Countrygirl Senior Member


    I have had a quick search and came up with the following:

    McClure was made Honorary Consultant in Genito-Urinary medicine in 1992.

    She gained her Ph.D. from Cambridge and worked for five years for the Institute of Cancer Research. She was awarded a D.Sc in medicine in 2002. At Imperial, she holds the Chair of Retrovirology and heads the section of infectious diseases.

    Last year, (not sure of the age of the article, so it may or may not mean 2009) she was appointed Director, Research and Development for St Mary's NHS Hospital Trust.

    She certainly isn't underqualified as a researcher!
  5. Gerwyn

    Gerwyn Guest

    What I,m really interested is her dual qualification what is a DSc in medicine is she medically qualified she must be but how
  6. lansbergen

    lansbergen Senior Member

  7. Gerwyn

    Gerwyn Guest

    What i,m trying to get at is she medically qualified an honorary consultantship must mean she is.Was she originally a medic
  8. Gerwyn

    Gerwyn Guest

    Uk XMRV positives beware wolves in sheeps clothing

    Wesselly and Mcclure have claimed that the BMJ misread the original proof copy of their BMJ article

    Meanwhile, a different strategy is also being considered to reconcile these different findings: that new blood samples should be take"n from patients with diagnosed chronic fatigue syndrome and sent to laboratories capable of carrying out the analysis. This is likely to happen [not "This is unlikely to be soon"] This is quite a proofreading error!


    On first reading this seems quite positive does it not.

    I am sure that most people remember the debacle when imperial college offered to test patients with prostate cancer for XMRV but would not accept patients with CFS.They then pulled this in seeming disarray.Why would they want to exclude patients with CFS

    If you read the comments in the bmj article above you would think that the idea was to take blood from CFS patients in the uk and send them to the wpi as at the moment it is the only group shown capable of doing the analysis

    BUT consider the following scenario

    The Imperial college develops a test that can detect XMRV in prostate cancer(I think this is what the hurried correction was about).

    This is announced The imperial college lab then becomes a "laboratory capable of carrying out the analysis"

    .They would have to ,in developing this test, exclude patients patients with CFS because negative results would prove their test did not work and positives would support the WPI.

    The next step would be to recruit XMRV positive positive patients from the uk to be retested in laboratories using this new technique.

    This technique would of course detect xmrv in prostate cancer but not have a prayer of doing so in CFS patients

    A negative result would then be used to completely discredit the WPI .The results must be due to contamination they would cry

    We would then have the Defreitas situation all over again.

    This scenario could of course lie wholly in my imagination but if it is real the quest for XMRV in ME/cfs would be dealt a savage blow

    To me this feels like a very clever trap

    I can only plead that people avoid being retested in any lab which cannot show publically that its tests can detect XMRV in blood samples sent by the WPI and go on public record as doing so.

    This scenario really frightens me

    Chronic fatigue syndrome and human retrovirus XMRV

    The online version of this editorial by Myra McClure and Simon Wessely contains an error (BMJ 2010;340:c1099, doi:10.1136/bmj.c1099). We misinterpreted an authors proof comment relating to the eighth paragraph, which should read: Meanwhile, a different strategy is also being considered to reconcile these different findings: that new blood samples should be take"n from patients with diagnosed chronic fatigue syndrome and sent to laboratories capable of carrying out the analysis. This is likely to happen [not "This is unlikely to be soon"]
  9. Knackered

    Knackered Guest

    I don't know a great deal about the Defreitas study, is it possible the virus Defreitas found was XMRV?
  10. garcia

    garcia Aristocrat Extraordinaire

    Talk about a Freudian slip! I thought the original sounded a bit too honest!

    Don't worry Gerwyn. This is not going to happen.
  11. Gerwyn

    Gerwyn Guest

    There are others who know more than me but her discovery was certainly quashed by political forces at least in my view
  12. Molly29


    Sorry Knackered, I was told by a good source that unfortunately the virus was not XMRV.

  13. _Kim_

    _Kim_ Guest

    Let's see if all of this adds up when I get a response to the FOI I submitted to I.C. about the XMRV test they offered on their website.

    By my calculations, I should be receiving a response from them by early next week (and julius sent in an FOI request soon after mine)
  14. leelaplay

    leelaplay member

    Charles Shepherd posted this to co-cure today

    ME/CFS, XMRV, DSM-V and the British Medical Journal - 6 March 2010

    Current issue contents:

    This week's edition of the British Medical Journal is concentrating on ME/CFS and XMRV.

    Besides having XMRV on the front cover there are seven other items:

    1 Editor's choice: 'Let's proceed with caution' by Fiona Godlee.

    2 Editorial: 'Chronic fatigue syndrome and human retrovirus XMRV' by Simon Wessely and Myra McClure (p489)

    3 Letter: 'More than defeatism greets patients with ME' from Stephanie Munn (p495)

    4 Letter: 'Severely affected, severely neglected' from Charles Shepherd (p495)

    5 Observations/Medicine and the media: Science, chronic fatigue syndrome, and ME by Cathie Sudlow (p510)

    6 Research highlights: Chronic fatigue syndrome and XMRV - reasons why the BMJ fast tracked the Dutch XMRV study and critical comments about the media publicity that accompanied publication of the Science paper in October 2009 (p516)

    7 Fast Track Research: Prevalence of XMRV in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort (summary of key points on p520)

    Up until now many clinical doctors in the UK have not even heard of XMRV and only a few knew about the possible link to ME/CFS.

    Things are about to change....

    There is also an editorial - 'If accepted, will fan the flames of false positive diagnoses' - on the first draft of DSM-V (p492)

    Post by The ME Association:
  15. Molly29


    Meant to include this...and leave it to your own minds to decide...;)

    "DeFreitas spoke next. . . . 'Clearly this virus is not HTLV-two. We now have additional data that verifies that point.'. . .Then DeFreitas moved on to the most interesting aspect of her work: the virus's appearance. 'We've look at four of these five cell lines. We can see particles by electron microscope, but not extracellular virus,' she said. 'We are not looking for a C-type retrovirus.' The significance of DeFreitas's comment most likely was appreciated by most present: every known human retrovirus was a C-type."

    Osler's Web
  16. Frickly

    Frickly Senior Member

    Thanks Islandfinn, Funny how the one disease that doctors and researchers avoided like the plague may become the center of the biggest medical discovery since HIV/AIDS. :Retro smile:
  17. natasa778

    natasa778 Senior Member

    How many clinical doctors in the UK know anything about CFS?
  18. V99


    This is likely to happen - strange grammer. The original seems more likely.
  19. garcia

    garcia Aristocrat Extraordinaire

    Pretty much zero.
  20. Gerwyn

    Gerwyn Guest

    Hi Garcia I have just seny the following to the BMJ

    erwyn j Morris,
    SA16 0AZ,
    Stephanie Fulton

    Send response to journal:
    Re: Re Edtorial on Chronic Fatigue Syndrome

    Dear Editor

    I am puzzled that so little is made of the relationship between the Oxford criterea and the failure of recent studies to detect XMRV.

    The following is a quote from one of theauthors of the Oxford criterea found in the CMO report of 2002 regarding said Oxford criterea.

    "British investigators have put forward an alternative, less strict, operational definition which is essentially chronic fatigue in the absence of neurological signs [but] with psychiatric symptoms as common associated features.” [12]

    would you seriously expect to find a virus in that population?

    Given that the virus which XMRV evolved from is found concentrated in lymphoid tissue.Why on earth didn't British researchers look there as the Americans did?

    If you went to a neurologist and he told you the following: " I can assure you that according to diagnostic critere created by my colleagues there is nothing wrong with you.Oh and by the way these diagnostic criterea are not internationally agreed " Would you be happy?

    Competing interests: None declared

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