M.S. of course is one of the most fatiguing and debilitating diseases known but its got nothing on ME/CFS when it comes to whacking a person where it really hurts - their functioning. I've read several times that for many people with MS their most disabling symptom is fatigue. That's too bad but ME/CFS patients were actually significantly worse off..... I don't recognize these London researchers but they did a great job highlighting how devastating ME/CFS is. ME/CFS patients scored not just lower but significantly lower in almost all the SF-36 functional domains and people with ME/CFS were particularly impaired with their ability to participate in physical activities. What a great advocacy tool this study is... (The best is still the huge 1996 Komaroff study which found reduced functional status compared to congestive heart failure (n = 216), type II diabetes mellitus (n = 163), acute myocardial infarction (n = 107), multiple sclerosis (n = 25), and depression (n = 502). https://www.ncbi.nlm.nih.gov/pubmed/8873490) It's great to see a more up to date study, though.