Hi guys, I'm new to the forum but was wondering if you could help me out. I've had CFS for 6.5 years and in recent months I've found out that I am MTHFR homozygous C677t. This is usually associated with high homocysteine, however, my recent blood tests (and tests I've had in the past) have come back low (4.7 umol/L, reference range 5 - 15). I I also have high B12 (serum and active). Can anyone tell me why my homocysteine is low? I've been supplementing with methylfolate and methylcobalamin for over six months but I haven't noticed any improvements. Do I need to supplement with glutathione and methionine? Thanks in advance.