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Low Dose Naltrexone Question: NK Cells and CD8

Discussion in 'General Treatment' started by PhoenixBurger, Mar 30, 2015.

  1. PhoenixBurger

    PhoenixBurger Senior Member

    If I had a dollar for every person who has suggested I try Low Dose Naltrexone, I would be rich. I finally was listening to Chris Kressers podcast today and he mentioned it as well. As it is a Central Nervous System sedative in some fashion (which is exactly what I need).

    My question about it however is this: I was reading that LDN actually increases activity of Natural Killer Cells and CD8 cells. ( regarding LDN and cancer: "By increasing the natural killer (NK) cell numbers and NK cell activity and lymphocyte activated CD8 numbers, which are quite responsive to increased levels of endorphins." ) (citation:

    My *only* abnormalities as far as bloodwork go, have been highly elevated NK Cells and very high CD8. Do I really want to be taking LDN if its going to raise them even further?

    Second question:

    I find it really strange that LDN apparently plays so much with endorphins. Nearly everything they say about it on the LDN website keeps referencing "endorphin" activity and "opiate receptors". First thing I thought was "Well no wonder people feel good on it. Its enhancing their feel good chemicals. But that doesn't mean its fixing their problem at all"

    Can anyone comment on this? I was expecting to read that LDN played some important roles in specific immune cell activity - calming autoimmunity and enhancing other immune cells. I was not expecting to read over and over about opiate receptors and endorphines.

  2. ahmo

    ahmo Senior Member

    Northcoast NSW, Australia
    I'm posting a piece written by a member of the LDN yahoo forum, a very well-informed participant and activist. I'm also adding some other links for you to check out. I've now been on LDN nearly 9 months. It has most certainly increased my stamina.
    picante and Sidereal like this.
  3. daisybell

    daisybell Senior Member

    New Zealand
    Naltrexone is an opioid receptor blocker. It was developed for use in treating opiate addiction and alcohol addiction. The effect of low doses is I think not well known, but it appears that it may be paradoxical, in that a low dose causes a rebound effect in endorphin release, hence making you feel better....
    If you look up naltrexone you can find details of how it works.
  4. Hanna

    Hanna Senior Member

    Jerusalem, Israel
    @PhoenixBurger , I have the same question, as my NK cells numbers are already high, and I have also elevated auto-antibodies (ANA, ScL, Sjogren etc). I was proposed LDN but would not want my immune system to 'fire' more than it already does.
    Justin30, belize44 and justy like this.
  5. Viewpoint


    There are no studies showing LDN increases NK cells or lymphocytes. It does the opposite - it stops the proliferation of cells that are highly active (proliferating) and in fact, by taking a low dose of naltrexone, you benefit from the upregulation of the body's own met enkephalin (known as OGF) which goes to work once LDN has cleared your receptors (4 hours later). The remaining 20 hours in a day suppresses the lymphocytes as these studies demonstrate:-

    T lymphocytes

    B lymphocytes

    And no, you certainly would not want to boost the activity of cells or fire up your immune system any more than it already does. These explanations how LDN works may help

    LDN and the immune system

    LDN and autoimmune disorders

    For Sjogrens, there is a well informed group about the use of LDN in Sjogrens, Lupus, RA and Scleroderma that is worth checking out on FaceBook
    belize44 and Hanna like this.
  6. MrME/CFS++



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