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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Lol, no great reaction yet, but I feel kinda cheerful.You had better tell us how you respond, or else!
400mcg, no headache, but I took two neurofen first.Headache? How much did you take?
Lol, no great reaction yet, but I feel kinda cheerful.
Yikes! My daughter's has been that low and she gets inosine. Hard to know what your doc is thinking. Maybe it has to do with how sensitive you are to meds...?
I don't know. Hence I am reporting on it as it happens.Just curious (to Alex and everyone)- if you are not taking Nitro for chest pressure, shortness of breath and angina, then what are you supposed to feel? This is not a sarcastic question and I am really asking.
Just curious (to Alex and everyone)- if you are not taking Nitro for chest pressure, shortness of breath and angina, then what are you supposed to feel? This is not a sarcastic question and I am really asking.
In healthy humans, continuous treatment with nitroglycerin (GTN) causes nitric oxide synthase dysfunction, probably through the reduced bioavailability of tetrahydrobiopterin.
Recent studies proposed that folic acid is involved in the regeneration of tetrahydrobiopterin in different disease states. Therefore, we investigated whether folic acid administration would prevent this phenomenon. We also sought to determine if folic acid supplementation could prevent the development of tolerance to GTN.
Our data demonstrate that supplemental folic acid prevents both nitric oxide synthase dysfunction induced by continuous GTN and nitrate tolerance in the arterial circulation of healthy volunteers. We hypothesize that the reduced bioavailability of tetrahydrobiopterin is involved in the pathogenesis of both phenomena. Our results confirm the view that oxidative stress contributes to nitrate tolerance.
This in itself is worth it! Being cheerful and also sick, deserves serious applause.I am almost never depressed or down, but for a while after taking the nitro I am cheerful. This has happened twice now. Is it boosting brain function?
I have a script for nitro right now, and I am hoping if I am well enough I might go with my shopper today and pick it up from the pharmacist. If so I will be testing it soon. I do wonder what percentage of us respond to this kind of therapy.
One thing it does seem to do is boost my mood. Almost immediately. I am almost never depressed or down, but for a while after taking the nitro I am cheerful. This has happened twice now. Is it boosting brain function?
It would be great if we could do some kind of PR study on this...enrol people ourselves into it BEFORE they try it and then find out how they went. If 20 of us did this.. we'd have a small study on our hands.
Nominating alex to be research subject 1