Hi,
@
caledonia, isn´t it only a hypothesis from Yasko that the mutations should be treated in that order? I do have respect for her experience, but Rich and Neil Nathan never stressed the CBS mutation as necessary to deal with in their clinical study. Maybe there are other opinions, but as far as I know there is no research so far.
At a ME-clinic in my country they have been giving treatment with folates and B12-injections for 15 years with very good results. Recently I talked to one of their doctors and showed results from 23and me and Yasko´s methylation test from 60 people. He got very excited to see that all had MTHFR mutations ( some heterozygote mutations should be added , so two heterozygote is as bad as being homozygote), and all had at least one MTRR mutation. This could explain their good results from treatment with B12-injections and folates, he thought, though it has to be studied and confirmed. The big problem is that there is no valid test for vitamin B12 today. Some tests might indicate a B12 deficiency but negative results are not valid. The absence of evidence is not the evidence for absence...That clinic give patients a trial treatment to see if they benefit from B12 and folate supplementation.
So a simple way could be to start with vitamin B12 and folates. Your MTHFR C677T mutation decreases your folate metabolism with 70 % so you do need extra methyltetrahydrofolate (
www.MTHFR.net ) and your MTRR mutation surely decreases you "recycling" of vitamin B12. I have a single MTRR mutation and I need injections every second day to fill my need of B12. Maybe you also will need extra potassium when you have started supplementation. I recommend reading posts about this.
PS I would recommend checking your detox panel too.
Best of luck!