Hypoxic ishemic encephalopathy

Might we have a milder version of this,I like the diagram on NMDA and Calcium,is it Calcium that does the damage and is this why low vit D levels maybe protective.http://neuropathology-web.org/chapter2/chapter2aHIE.html

 

Calcium levels in the body are tightly regulated. They shouldn't move up or down much over a wide variety of vitamin D. The vitamin D3 you buy in the drugstore (or make in response to sunlight) is not active at the VDR (vitamin D receptor). Levels of the active form (calcitriol, available for supplementation only by prescription, as too much is very dangerous, aka 1,25 dihydroxy vitamin D) are often a thousand fold lower than the inactive form.

Activation of Vitamin D is accomplished in a stepwise fashion in the liver and kidneys, and the rate of this conversion is controlled so as to prevent hypocalcemia or hypercalcemia.

How much D you take isn't really going to significantly affect calcium influx through glutamate channels (NMDA and AMPA are different types of glutamate channels - NMDA has a much greater permeability to Ca++ than AMPA, which is more selective for monovalent cations such as Na+ and K+).

I don't think this has anything to do with the role of Vitamin D, and whether or not higher or lower levels may or may not be protective in ME.

I do think there is a good body of evidence suggesting a role for overactivation of glutamate channels. A number of mechanisms may be involved in this.