Hi Rossy,
I compared the numbers you gave with the Iron Disorders charts. It would be helpful if you had a full iron panel done, so you could compare all the numbers with the charts.
So, did you mean you have one C282Y? Did they look at H63D? If you have one of those, too, then you'd be compound heterozygous like me. My case went under the radar as my doctor was expecting to see a serum ferritin over 1000 but mine was a milder case as the C282Y homozygous cases are worse than the H63D.
Even with the one copy, it might just be a milder case. It's hard to tell exactly, because you didn't give numbers for all the columns, but following the flow chart on page 1, given that you've had elevated ALT and AST, it might be reasonable to do a trial phlebotomy. The doctor ordered a smaller amount taken out of me, only 250ml at a time, so as not to shock my body.
But, looks like it could also be sideroblastic anemia (B6 deficiency), B12 deficiency, thalassemia, or porphyria. You'd have to dig into the details of those.
If it is hemachromatosis, though, the iron overload is bad for your mitochondria, bad for your liver, etc. and can cause fatigue, as well as feeding any infections that might be lurking. MY ME/CFS specialist was very on biard with my getting rid of extra iron. You'll need to get rid of it. There is a chelator for it, but that can be hard on your body, it's easier just to get rid of it. It's a pretty simple process.
And, any of the other possibilities can contribute to your symptoms. Worth investigating each. What's your MCV or methylmalonic acid like? Homocysteine? B6? TIBC? UIBC?