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Help With Blood Results Please

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by Vigilante, Feb 18, 2014.

  1. Vigilante


    Hello all,

    Two blood results that interest me that have came up are:

    High Serum Vitamin B12 - on 3 seperate occasions and I have not ever taken B12 as a supplement or indeed any Multi Vitamin Supplement for years.

    High Serum IgA - Due to the IgA and B12 I was sent to a Blood specialist to rule out the likes of Multiple Myeloma, Leukemia, Lymphoma.

    Nothing was found on a physical exam, nodes fine, spleen fine, etc. I was blood tested for various things like Para-protein, Jak2 Mutation, Calcium, LDH, CBC, bone, and others - all were negative and fine. I was then discharged.

    I have also been tested for Celiac Disease via the blood tests but they were also negative, although I do happen to get cramping of my lower intestine randomly.

    The results still interest me because I have a host of symptoms over the past 1.5 years that are so far unexplained and these results are the only things that have so far been found.

    symptoms like:

    Neuropathy - Tingling/burning of my hands and feet
    Increased Sweating

    Any ideas on what would be worth exploring? I'm still wondering if this high b12 could actually mean a functional deficiency?
  2. Ema

    Ema Senior Member

    Midwest USA
    Your symptoms sound autonomic in nature so if you've only had a standard celiac test, I would get a more advanced one or simply go gluten free for at least 6 months to a year.

    You may also have a gut infection and a stool test/digestive function test may be helpful.

    Check out these references:


    Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome
    Michael Maes Frank N.M. Twisk Marta Kubera Karl Ringel Jean-Claude Leunis Michel Geffard
    Abstrakt, słowa kluczowe




    Dodatkowe informacje
    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is accompanied by a) systemic IgA/IgM responses against the lipopolysaccharides (LPS) of commensal bacteria; b) inflammation, e.g. increased plasma interleukin-(IL)1 and tumor necrosis factor (TNF)α; and c) activation of cell-mediated immunity (CMI), as demonstrated by increased neopterin.To study the relationships between the IgA/IgM responses to the LPS of microbiota, inflammation, CMI and the symptoms of ME/CFS we measured the IgA/IgM responses to the LPS of 6 different enterobacteria, serum IL-1, TNFα, neopterin, and elastase in 128 patients with ME/CFS and chronic fatigue (CF). Severity of symptoms was assessed by the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale.Serum IL-1, TNFα, neopterin and elastase are significantly higher in patients with ME/CFS than in CF patients. There are significant and positive associations between the IgA responses to LPS and serum IL-1, TNFα, neopterin and elastase. Patients with an abnormally high IgA response show increased serum IL-1, TNFα and neopterin levels, and higher ratings on irritable bowel syndrome (IBS) than subjects with a normal IgA response. Serum IL-1, TNFα and neopterin are significantly related to fatigue, a flu-like malaise, autonomic symptoms, neurocognitive disorders, sadness and irritability.The findings show that increased IgA responses to commensal bacteria in ME/CFS are associated with inflammation and CMI activation, which are associated with symptom severity. It is concluded that increased translocation of commensal bacteria may be responsible for the disease activity in some ME/CFS patients.
    Last edited: Feb 18, 2014
  3. taniaaust1

    taniaaust1 Senior Member

    Sth Australia
    I dont know myself but I have heard others talk about functional B12 deficiency and I do know that tingling/burning of hands and feet can be a sign of B12 deficiency amount other things. B12 deficiency signs can start in body extremeties.

    Maybe you should consider a trial of an active B12 form to see how that affects your body to find out.

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