Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Help me interpret my SNP, please )

Discussion in 'Genetic Testing and SNPs' started by Andey, Mar 23, 2015.

  1. Andey


    Hello everybody
    This is my first post here, so I will introduce myself - Andriy, live in Kiev, Ukraine
    I struggle with anxiety, IBS-C symthoms, fevers. Local healthservice happens to be useless in my case, so I take investigation in my hands.

    As I understand I have some nastiest SNP combinations.
    Enlight me please, is it as serious as I think ?

    Gene & Variation rsID Alleles Result
    COMT V158M rs4680 AA +/+
    COMT H62H rs4633 TT +/+

    COMT P199P rs769224 GG -/-
    VDR Bsm rs1544410 TT +/+
    VDR Taq rs731236 GG -/-
    MAO-A R297R rs6323 GG -/-

    ACAT1-02 rs3741049 AG +/-
    MTHFR C677T rs1801133 AA +/+
    MTHFR 03 P39P rs2066470 GG -/-
    MTHFR A1298C rs1801131 TT -/-

    MTR A2756G rs1805087 AG +/-
    MTRR A66G rs1801394 GG +/+
    MTRR H595Y rs10380 __ no call
    MTRR K350A rs162036 AA -/-
    MTRR R415T rs2287780 __ no call
    MTRR A664A rs1802059 GG -/-
    BHMT-02 rs567754 CT +/-
    BHMT-04 rs617219 __ no call
    BHMT-08 rs651852 TT +/+
    AHCY-01 rs819147 CT +/-
    AHCY-02 rs819134 __ no call
    AHCY-19 rs819171 CT +/-
    CBS C699T rs234706 GG -/-
    CBS A360A rs1801181 AA +/+
    CBS N212N rs2298758 __ no call
    SHMT1 C1420T rs1979277 __ no call

    If it helps I have measured
    folic acid 16.7 (5-17)
    serum B12 (cyanocobalamin) 360 (191,0–663,0)
    As I understand folic acid and cyanocobalamin levels are not really relevant in my situation

    Thanks in advance )

    P.S Should I do homocysteine test ?
    Last edited: Mar 23, 2015
  2. pogoman

    pogoman Senior Member

    With you having two copies of the MTHFR C677T I would recommend the homocysteine test as it can be raised due to MTHFR.
    I cannot advise you on your other SNPs but for MTHFR treatment look in the Detox: Methelation forum at the various B12 and methylation protocols in the stickies.
    I recommend staying away from folic acid also.
    Andey likes this.
  3. Andey


    Thanks pogoman )

    I am little bit pussled about road I need to choose because I am not experiencing any fatique symptoms and on this basis probably dont have ME/CFS as it is. Though I have a lot of related issues like IBS and anxiety that probably caused by my methylation gene defects. I read a bunch of topics on Detox: Methelation forum and saw a lot of people performing Methelation protocols that dont really have a major disruptancies in their MTR/MTRR or MTHFR.
    So are those protocols about empirically deal with CE/MFS or actual pathway anomalities ? Should I take them as granted or maybe there are some lighter protocols to just compensate methylation ?
  4. pogoman

    pogoman Senior Member

    You're welcome, the thing about MTHFR is it can cause issues that may seem unrelated at first.
    And fixing methylation is important to repairing MTHFR.
    I have seen every kind of specialist the past 3 years for my pain and fatigue symptoms and all they came up with is unknown non-inflammatory myopathy.
    For over a decade I have had IBS, anemia and secondary hypogonadism and they couldn't figure out why.
    I even had a genetic specialist doctor tell me last year my double MTHFR mutation was not the cause of my issues.
    Yet about that time, after taking mitochondrial supplements that got me off pain meds and then starting on what became identical to freddds methylation protocol, I am feeling much better.

    When I joined here, I posted my SNPs here and I didn't get any replies.
    When you google MTHFR treatment this site gets alot of hits, there are a high percentage of people here with MTHFR mutations of different kinds.
    So searching thru all the threads will be helpful altho time consuming.

    Your SNP results are from 23andme?
    If so have you tried running your results thru an online analyzer like Genetic Genie or Promethease?
    This would help pinpoint other problem SNPs you can then research.
    Andey likes this.
  5. Andey


    My story is shorter but similar. I started with gastroenterology for IBS and GERD, was treated againt Helicobacter infection and send off ) Then I found swollen lymph nodes in cervical area and on and so on.

    Is your IBS resolved by treatment ? Its kind of major thing for me coz I still didnt found a way to deal with it.

    Yep, I ran it through GG and Promethease. Actually this is a GG report on the top and when I saw it first time I was shocked...but it could explain almost all my problems. Question is to how deal with them.
    My B12 and folate supplements are on the way already, I only struggle with the fact that my COMT++ mutations seems to be restrictive on mB12. This means I cannot use Fredds megadose mB12 approach. Hopefully somebody would explain me how restrictive it is, I dont found any COMT++ participants in Freeds protocol yet, so I have nobody to ask about it. As I see it now my main problem is not a MTHFR++ but MTR/MTRR double whammy ((
  6. pogoman

    pogoman Senior Member

    My ibs is probably the result of having diverticulosis.
    I was diagnosed with it a few years ago and I realize now that much of the ibs symptoms I've had since my 20s are the same as diverticulosis.
    I have been taking Imodium as needed along with fiber and greek yogurt, some of my supplements are hard on the intestinal system so I spread them out with food.

    I think you are going to have to research your individual SNPs here and online and do supplement trials to see what you tolerate.
    Thats how I have been making progress since last year.
    The Detox forum has been helpful to me in learning more about specific issues and questions.
    While I do have a couple of homozygous COMT snp's (different from yours) I have never had any problems taking high dosage B12 or folate.
    And you may find that some of your red SNP's can be ignored.
    I would read the protocols and start out slow.
    Just remember everybody is different and tweaking your supplements is probably going to be necessary.

    Another 23andme analyzer is Sterling's App at
    They just came out with version 2 with more SNPs checked and links built in to SNPedia for each SNP.

    some links you may want to check out, I do not agree with everything in them but there is good info there.

    Also do a search here for a member named caledonia, she has a bunch more links in her signature including a SNP guide.
    Andey likes this.

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