POTS is a product of autonomic dysfunction, a defect in acetylcholine signalling affecting vagus nerve function I think was what Dr Driscoll was getting at.
Antibodies to adrenergic and (muscarinic) acetylcholine receptors are another factor to result in POTS andI've become aware recently that a lot of people who have left renal vein compression (Renal Nutcracker Syndrome) also have POTS.
Dr Driscoll was looking at increased intracranial pressure as a big factor which is something that can occur in those with LRV compression where excess venous pressure is refluxed into the spinal tract, something called midline congestion syndrome.
http://scholbach.de/en/wissenschaft...elliniensyndrom-mittellinien-stauungs-syndrom