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Hägglöf et al: Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses

Discussion in 'Other Health News and Research' started by mango, Nov 2, 2016.

  1. mango

    mango Senior Member

    Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses

    Thomas Hägglöf, Saikiran K Sedimbi, Jennifer L Yates, Roham Parsa, Briana Hauff Salas, Robert A Harris, Elizabeth A Leadbetter & Mikael C I Karlsson

    Nature Immunology (2016) doi:10.1038/ni.3583
    Published online 31 October 2016

    The innate responsiveness of the immune system is important not only for quick responses to pathogens but also for the initiation and shaping of the subsequent adaptive immune response. Activation via the cytokine IL-18, a product of inflammasomes, gives rise to a rapid response that includes the production of self-reactive antibodies. As increased concentrations of this cytokine are found in inflammatory diseases, we investigated the origin of the B cell response and its regulation.

    We identified an accumulation of B cell–helper neutrophils in the spleen that interacted with innate-type invariant natural killer T cells (iNKT cells) to regulate B cell responses. We found that neutrophil-dependent expression of the death-receptor ligand FasL by iNKT cells was needed to restrict autoantibody production. Neutrophils can thus license iNKT cells to regulate potentially harmful autoreactive B cell responses during inflammasome-driven inflammation.

    Subject terms: Autoimmunity, Inflammation, Innate immune cells
    Thinktank and nandixon like this.
  2. mango

    mango Senior Member

    Karolinska Institutet:
    How autoimmune disease is prevented – mechanism discovered
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  3. alex3619

    alex3619 Senior Member

    Logan, Queensland, Australia
    It makes me wonder how much our defective NK cell responses are permitting abnormal B cell responses.
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  4. JamBob

    JamBob Senior Member

    Good spot @mango

    I was interested to read on the wikipedia page for neutrophils that "Decreases in neutrophil function have been linked to hyperglycemia. Dysfunction in the neutrophil biochemical pathway myeloperoxidase as well as reduced degranulation are associated with hyperglycaemia."

    Has anyone tested neutrophils in ME/CFS?

    I'm a T1 diabetic (so I always have some degree of hyperglycaemia) and have another autoimmune disease (Thyroid) and whatever ME is (I'm leaning to autoimmune but I want to stay open-minded).

    My mum frequently has neutropenia (low neutrophil count) and I sometimes do. People with T1 diabetes apparently also have low levels of iNKT (along with people with SLE, lupus and other autoimmune disease).

    I need to read up on some immunology!! ;);)
    Webdog likes this.

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