"Our research raises the intriguing possibility that the gut microbiota may play an important role in response to vaccines and susceptibility to enteric pathogens, or bacteria that affect the intestinal tract," says the senior author on both papers, Claire M. Fraser, Ph.D., Professor of the Departments of Medicine and Microbiology and Immunology and director of the Institute for Genome Sciences (IGS) at the University of Maryland School of Medicine.
... Differences in the effectiveness of experimental vaccines have been attributed to heterogeneous immunogenicity among subjects, host genetics, nutrition, socioeconomic status and other factors. Researching the impact of the composition of intestinal microbiota is a new approach made possible by state-of-the-art advances in high-throughput sequencing technologies.
http://www.sciencedaily.com/releases/2013/06/130605185931.htm