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FMT in ulcerative colitis reveals associated gut microbial and host metabolic reprogramming.

Discussion in 'Other Health News and Research' started by Murph, May 9, 2018.

  1. Murph

    Murph :)

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    (I share this piece mostly because it finds a link from gut microbiome to metabolism. Support for all the people out there who think the gut could be tied up in me/cfs.)

    Fecal microbiota transplantation in experimental ulcerative colitis reveals associated gut microbial and host metabolic reprogramming.
    Yan Z1,2, Gao XJ1,2, Li T1,2, Wei B1,2, Wang P1,2, Yang Y1,2, Yan R3,2.
    Author information
    Abstract

    Fecal microbiota transplantation (FMT) is gaining attention for the treatment of ulcerative colitis (UC). Data from individual case studies have suggested that FMT may be beneficial for UC but the detailed microbial and molecular basis remains unknown. Here, we employ 16S rRNA gene sequencing and metabolomics to investigate the influence of FMT on gut microbial community composition and host metabolism in the dextran sulfate sodium (DSS) induced UC rat model.

    The findings from this pilot study suggest that FMT from normal donors to UC recipients could alleviate UC symptoms without close resemblance of donor's gut microbial and metabolic pattern. Meanwhile, FMT from UC donors to normal recipient rats triggered UC symptoms, UC-prone microbial shift, and host metabolic adaption. Gut microbiota under normal conditions could maintain stable species richness and diversity upon FMT intervention but the disturbed gut microbiota under UC conditions could not maintain such homeostasis. Significant correlations between altered bacterial composition and host metabolism could be assigned to the pathological effects of UC (accounting for 8.0-16.2% of total variance) and/or the FMT intervention effects (3.9%-7.0% of total variance).

    Overall, our study reveals diverse gut microbial shifts in UC related FMT and their association with host metabolic reprogramming.

    IMPORTANCE
    This study combined clinical symptoms measurement, 16S rRNA gene microbial profiling and metabolomics to comprehensively investigate the gut bacterial and host metabolic association and reprogramming in FMT treated experimental UC. These data can advance our understanding of the effect of FMT on UC and the involvement of gut microbial dysbiosis in the development of UC.

    PMID:
    29728388
    DOI:
    10.1128/AEM.00434-18
     

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