Our Newly Ill Face Their First Holiday Season with ME/CFS
Don't look now! The holiday season is on its way. I've lived through decades of them with ME/CFS. So have many of you in our chronically ill community. That's beyond sad for all of us. But at least we have some idea what we're contending with, and have learned our ways of handling...
Discuss the article on the Forums.

Extracorporeal photopheresis

Discussion in 'Other Health News and Research' started by user9876, Oct 7, 2012.

  1. user9876

    user9876 Senior Member

    Messages:
    2,586
    Likes:
    18,197
    I came across this technique recently and thought it might interest people here since it is aimed at immune mediated diseases.Or to be more accurate t-cell lymphoma and graft vs host disease, there seems to have been some work in autoimmune disease as well but I've not managed to track down papers yet. I don't think i've seen it discussed here.

    I thought what was interesting is that they talk of chaning ratios of different parts of the immune system and the effects that treating around 10% of cells seems to have on the rest.

    For example

    and
    As I understand it the technique it involves taking blood out, separating out the t-cells via a centrafuse treating them with UV light and a chemical then putting them back.

    A couple of papers

    http://www.nature.com/bmt/journal/v29/n9/full/1703529a.html
    http://bloodjournal.hematologylibrary.org/content/112/4/1515.full
     
    Jesse2233 likes this.
  2. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,942
    Likes:
    5,310
    Southern California
    Has anyone had this? My immunologist just recommended it
     
    Nickster and shannah like this.
  3. Gingergrrl

    Gingergrrl Senior Member

    Messages:
    12,578
    Likes:
    36,493
    Hi Jesse, what is it? It this similar to PP or something else? Can you explain it in non-sciency terms? :D
     
    crypt0cu1t likes this.
  4. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,942
    Likes:
    5,310
    Southern California
    Hahah I'll do my best!

    So as I understand, it basically removes a portion of your blood, separates out the white cells, treats them with a special chemical and ultraviolet light which kills them, and then puts everything back into your body using two peripheral lines. It's done bi-weekly over a period of 6 months. They're not sure exactly how it works, but one theory is that the dead immune cells send a signal to the body to increase T-regs which in turn lower inflammation, clear chronic pathogens, and destroy autoantibodies.

    I talked to my doctor about photopheresis vs immunoadsorbtion and plasmapheresis and he said that if it works, the benefit would be longer (or even permanent) with photopheresis because there's a potential for immune reset.

    It's considered to be safer than immunosuppression and so can be used in cases where chronic infections might be present.

    It's usually done for cancer and organ transplant but new data is showing benefit for autoimmunity as well. I would be patient zero for my case however, which my doctor made very clear

    I thought the T cell mechanism of action was interesting given Mark Davis' findings and what Dr Chia told me last appointment about Dr Klimas' T-cell treatment experiment
     
    Hanna, perrier and Gingergrrl like this.
  5. crypt0cu1t

    crypt0cu1t IG: @skagginwagon

    Messages:
    264
    Likes:
    569
    California
    Do you h
    Do you happen to know who Jesses immunologist was?
     

See more popular forum discussions.

Share This Page