http://slatestarcodex.com/2017/08/29/my-irb-nightmare/ This is a long piece but a good one, outlining one young psychiatrist's attempt to run a study, and the insane bureaucracy that ensued. Some key paragraphs from near the end of the piece: I’m capable of doing research, I think I have something to contribute to Science. I still think the bipolar screening test is inappropriate for inpatient diagnosis, and I still think that patients are being harmed by people’s reliance on it. I still think somebody should look into it and publish the results. I’m just saying it’s not going to be me. I am done with research. People keep asking me “You seem really into science, why don’t you become a researcher?” Well… I feel like a study that realistically could have been done by one person in a couple of hours got dragged out into hundreds of hours of paperwork hell for an entire team of miserable doctors. I think its scientific integrity was screwed up by stupid requirements like the one about breaking blinding, and the patients involved were put through unnecessary trouble by being forced to sign endless consent forms screaming to them about nonexistent risks. I feel like I was dragged almost to the point of needing to be in a psychiatric hospital myself, while my colleagues who just used the bipolar screening test – without making the mistake of trying to check if it works – continue to do so without anybody questioning them or giving them the slightest bit of aggravation. I feel like some scientists do amazingly crappy studies that couldn’t possibly prove anything, but get away with it because they have a well-funded team of clerks and secretaries who handle the paperwork for them. And that I, who was trying to do everything right, got ground down with so many pointless security-theater-style regulations that I’m never going to be able to do the research I would need to show they’re wrong.