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Environmental triggers in retroviruses

Discussion in 'Media, Interviews, Blogs, Talks, Events about XMRV' started by leelaplay, Jan 16, 2010.

  1. leelaplay

    leelaplay member

    kelly posted this to co-cure 2010 01 12

    Environmental triggers in retroviruses

    Lupus. 2009 Nov;18(13):1136-43.

    Cross-talk of the environment with the host genome and the immune system through endogenous retroviruses in systemic lupus erythematosus**

    Blank M, Shoenfeld Y, Perl A.

    Center for Autoimmune Diseases, an Department of Medicine B, Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Hashomer, Israel.

    Environmental factors are capable of triggering the expression of human endogenous retroviruses and induce an autoimmune response.

    Infection can promote the expression of human endogenous retroviruses by molecular mimicry or by functional mimicry. There are additional mechanisms which may control the expression of human endogenous retroviruses, such as epigenetic status of the genome (hypomethylation, histone deacetylation).

    Ultraviolet exposure, chemicals/drugs, injury/stress, hormones, all as a single cause or in a concert, may modulate the involvement of human endogenous retroviruses in pathogenic processes.

    In the current review we summarize the current knowledge on infections, molecular mimicry, cross-reactivity and epigenetics contribution for trigger human endogenous retroviruses expression and pathogenesis in lupus patients.

    PMID: 19880559 [PubMed - indexed for MEDLINE]
  2. This is interesting, would this explain why so many ME patients report feeling worse or even have a relapse after extensive time in sunlight? (e.g. sunbathing).
  3. flybro

    flybro Senior Member

    This intrests me as well
    I have gone from someone that was always in the sun, I worked as a gardner and was never in doors in the summer.

    Now I can hardly tolerate it, and it does magnify my symptoms.
  4. Hysterical Woman

    Hysterical Woman Senior Member

    East Coast

    Hi IF,

    Thanks for the post - very interesting. I was working at a hazardous waste disposal facility when I became ill. Both my primary care doc and Dr. Lerner believe that it is a high probability that it was a contributing factor.

    Take care,

  5. usedtobeperkytina

    usedtobeperkytina Senior Member

    Clay, Alabama
    So if it turns on endogenous viruses, then does this reaction cause an illness? If so, then endogenous viruses are not necessarily always benign. If it doesn't cause illness, then the question is still out there, with the assumption remaining that endogenous viruses do not cause illness.

    I just don't think we know enough to make blanket statements about viruses and their behavior. It used to be thought viruses had no role in cancer, now we know they can. Stomach uclers were thought to be caused by stress, now we know it is an infection.

    Come on scientists, leave the old paradigms behind and open your mind. Remember, discovery only comes when someone goes looking for something new and different.


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