I've picked up from a Lyme forum.
It shows that it's more beneficial to take probiotics whilst on abx, rather than post-abx
http://www.ncbi.nlm.nih.gov/pubmed/22452835
BMC Microbiol. 2012 Mar 27;12(1):47.
Effects of probiotics and antibiotics on the intestinal homeostasis in a
computer controlled model of the large intestine.
Rehman A, Heinsen FA, Koenen M, Venema K, Knecht H, Hellmig S, Schreiber
S, Ott SJ.
ABSTRACT:
BACKGROUND:
Antibiotic associated diarrhea and Clostridium difficile infection are
frequent complications of broad spectrum antibiotic therapy. Probiotic
bacteria are used as therapeutic and preventive agents in these
disorders, but the exact functional mechanisms and the mode of action
are poorly understood. The effects of clindamycin and the probiotic
mixture VSL#3 (containing the 8 bacterial strains Streptococcus
thermophilus, Bifidobacterium breve, Bifidobacterium longum,
Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus
plantarum, Lactobacillus paracasei and Lactobacillus delbrueckii subsp.
Bulgaricus) consecutively or in combination were investigated and
compared to controls without therapy using a standardized human fecal
microbiota in a computer-controlled in vitro model of large intestine.
Microbial metabolites (short chain fatty acids, lactate, branched chain
fatty acids, and ammonia) and the intestinal microbiota were analyzed.
RESULTS:
Compared to controls and combination therapy, short chain fatty acids
and lactate, but also ammonia and branched chain fatty acids, were
increased under probiotic therapy. The metabolic pattern under combined
therapy with antibiotics and probiotics had the most beneficial and
consistent effect on intestinal metabolic profiles. The intestinal
microbiota showed a decrease in several indigenous bacterial groups
under antibiotic therapy, there was no significant recovery of these
groups when the antibiotic therapy was followed by administration of
probiotics. Simultaneous application of anti- and probiotics had a
stabilizing effect on the intestinal microbiota with increased
bifidobacteria and lactobacilli.
CONCLUSIONS:
Administration of VSL#3 parallel with the clindamycin therapy had a
beneficial and stabilizing effect on the intestinal metabolic
homeostasis by decreasing toxic metabolites and protecting the endogenic
microbiota from destruction. Probiotics could be a reasonable strategy
in prevention of antibiotic associated disturbances of the intestinal
homeostasis and disorders.
PMID:
22452835
[PubMed - as supplied by publisher]
It shows that it's more beneficial to take probiotics whilst on abx, rather than post-abx
http://www.ncbi.nlm.nih.gov/pubmed/22452835
BMC Microbiol. 2012 Mar 27;12(1):47.
Effects of probiotics and antibiotics on the intestinal homeostasis in a
computer controlled model of the large intestine.
Rehman A, Heinsen FA, Koenen M, Venema K, Knecht H, Hellmig S, Schreiber
S, Ott SJ.
ABSTRACT:
BACKGROUND:
Antibiotic associated diarrhea and Clostridium difficile infection are
frequent complications of broad spectrum antibiotic therapy. Probiotic
bacteria are used as therapeutic and preventive agents in these
disorders, but the exact functional mechanisms and the mode of action
are poorly understood. The effects of clindamycin and the probiotic
mixture VSL#3 (containing the 8 bacterial strains Streptococcus
thermophilus, Bifidobacterium breve, Bifidobacterium longum,
Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus
plantarum, Lactobacillus paracasei and Lactobacillus delbrueckii subsp.
Bulgaricus) consecutively or in combination were investigated and
compared to controls without therapy using a standardized human fecal
microbiota in a computer-controlled in vitro model of large intestine.
Microbial metabolites (short chain fatty acids, lactate, branched chain
fatty acids, and ammonia) and the intestinal microbiota were analyzed.
RESULTS:
Compared to controls and combination therapy, short chain fatty acids
and lactate, but also ammonia and branched chain fatty acids, were
increased under probiotic therapy. The metabolic pattern under combined
therapy with antibiotics and probiotics had the most beneficial and
consistent effect on intestinal metabolic profiles. The intestinal
microbiota showed a decrease in several indigenous bacterial groups
under antibiotic therapy, there was no significant recovery of these
groups when the antibiotic therapy was followed by administration of
probiotics. Simultaneous application of anti- and probiotics had a
stabilizing effect on the intestinal microbiota with increased
bifidobacteria and lactobacilli.
CONCLUSIONS:
Administration of VSL#3 parallel with the clindamycin therapy had a
beneficial and stabilizing effect on the intestinal metabolic
homeostasis by decreasing toxic metabolites and protecting the endogenic
microbiota from destruction. Probiotics could be a reasonable strategy
in prevention of antibiotic associated disturbances of the intestinal
homeostasis and disorders.
PMID:
22452835
[PubMed - as supplied by publisher]
