The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Effects of probiotics and antibiotics on the intestinal homeostasis

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by xrunner, Mar 31, 2012.

  1. xrunner

    xrunner Senior Member

    I've picked up from a Lyme forum.
    It shows that it's more beneficial to take probiotics whilst on abx, rather than post-abx

    BMC Microbiol. 2012 Mar 27;12(1):47.

    Effects of probiotics and antibiotics on the intestinal homeostasis in a
    computer controlled model of the large intestine.

    Rehman A, Heinsen FA, Koenen M, Venema K, Knecht H, Hellmig S, Schreiber
    S, Ott SJ.



    Antibiotic associated diarrhea and Clostridium difficile infection are
    frequent complications of broad spectrum antibiotic therapy. Probiotic
    bacteria are used as therapeutic and preventive agents in these
    disorders, but the exact functional mechanisms and the mode of action
    are poorly understood. The effects of clindamycin and the probiotic
    mixture VSL#3 (containing the 8 bacterial strains Streptococcus
    thermophilus, Bifidobacterium breve, Bifidobacterium longum,
    Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus
    plantarum, Lactobacillus paracasei and Lactobacillus delbrueckii subsp.
    Bulgaricus) consecutively or in combination were investigated and
    compared to controls without therapy using a standardized human fecal
    microbiota in a computer-controlled in vitro model of large intestine.
    Microbial metabolites (short chain fatty acids, lactate, branched chain
    fatty acids, and ammonia) and the intestinal microbiota were analyzed.


    Compared to controls and combination therapy, short chain fatty acids
    and lactate, but also ammonia and branched chain fatty acids, were
    increased under probiotic therapy. The metabolic pattern under combined
    therapy with antibiotics and probiotics had the most beneficial and
    consistent effect on intestinal metabolic profiles. The intestinal
    microbiota showed a decrease in several indigenous bacterial groups
    under antibiotic therapy, there was no significant recovery of these
    groups when the antibiotic therapy was followed by administration of
    probiotics. Simultaneous application of anti- and probiotics had a
    stabilizing effect on the intestinal microbiota with increased
    bifidobacteria and lactobacilli.


    Administration of VSL#3 parallel with the clindamycin therapy had a
    beneficial and stabilizing effect on the intestinal metabolic
    homeostasis by decreasing toxic metabolites and protecting the endogenic
    microbiota from destruction. Probiotics could be a reasonable strategy
    in prevention of antibiotic associated disturbances of the intestinal
    homeostasis and disorders.

    [PubMed - as supplied by publisher]
  2. determined

    determined Senior Member

    USA: Deep South
    This is good to know, thanks for posting. I've always assumed this was true, but it's nice to have some real evidence.
  3. Enid

    Enid Senior Member

    Thanks for posting xrunner - I did use probiotics (at special times) during a course of abx and afterwards - good to see confirmation of the benefits.
  4. Lotus97

    Lotus97 Senior Member

    United States
    I might have to take antibiotics again so I'm wondering when I should take the probiotics because I don't want to get diarrhea again. I assume I'll be taking the ABX 4 times a day.

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