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Dr. Peterson presentation from Calgary April 29th - May 1st

Discussion in 'General ME/CFS News' started by August59, May 15, 2011.

  1. August59

    August59 Daughters High School Graduation

    Upstate SC, USA
    This didn't seem to generate much discussion in an earlier thread, but may have been due to timing of the Singh paper. Some of this was already pretty well known, but parts of it I hope would generate some more discussion.

    The section about the CMX001 was good news. The section about the spinal fluid seemed to cover a little more than I had heard of before. The "FUTURE" section mentioned the word "Translational", which seems to be a catchy term used these days!
  2. Cort

    Cort Phoenix Rising Founder

    That's a fascinating presentation.a

    Will people with some psychiatric disorders end up having herpesvirus infections? Why not? Could some of the depression/anxiety in CFS be due to infections? Why not?

    He is VERY HIGH on CFIDOVIR and is starting a trial at his office. They came to him actually. If the problem is getting at the herpesviruses (and that does seem to be the problem in CFS eg the long treatment times) and CFIDOVIR is better at that - it could be a huge breakthrough.....

    Could we start seeing dramatically increased rates of improvement/wellness in people taking this drug. If Montoya had had this drug would his antiviral trial had a much different outcome? If this drug works it could have a major impact on how this disorder is viewed.

    Lots of interesting stuff going on.

  3. Cort

    Cort Phoenix Rising Founder

    6-8%of SARS patients come down with ME/CFS - suggesting what? Probably that the type of infection may not be important but that an infection in susceptible people changes may trigger a cytokine cascade that damages something in brain or sensitizes the brain to cytokines - keeping the immune cells in the brain activated all the time.

    I just met Dr. Peterson in Incline with Corrine Blandino and he thinks its all in the brain. Something happens that triggers problems in the brain.....

    He said his 'filter' for CFS was natural killer cell functioning. He uses that test to determine if he will see a patient or not...That is the type of patient he focuses on. They don't always have a pathogen (that he can find) but they always have NK cell dysfunction...

  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

    australia (brisbane)
    Interesting, i heard that peterson is in talks with the aussie university (Bond University) that is currently undertaking a cfs study on nk dysfunction, the study's main aim was to design a test for cfs/me.
  5. Overstressed

    Overstressed Senior Member

    Hi Cort,

    if the filter is NK-cell functioning, is that then not evidence for an underlying retrovirus infection ? I've never heard that herpes viri can cause that... I think it all comes down to this: you have an underlying XMRV infection, and all you need is a trigger. The problem is not the trigger, but the underlying cause. It's like HIV and AIDS. If there's no HIV, you simply don't get AIDS.

    Best regards,
  6. Cort

    Cort Phoenix Rising Founder

    Certainly the retrovirus model - of a retrovirus depleting the immune system enough so that other pathogens can come in. If XMRV works out I think it could apply to B-cells since XMRV does appear to be able to replicate in them.

    Other viruses can and do effect immune functioning. Some of them even live in immune cells. I don't know if they can match up natural killer cell dysfunction with a specific type of virus. We do know that Peterson finds and treats herpes viruses in his patients.

    I did ask him if someday researchers will at some point be able to associate a specific kind of immune hole with a specific type of pathogen and he said yes. He believes the fact someone has a pathogen means they have an hole in their immune system and my sense was that he believes if he can patch that hole (and get rid of the virus) then the problems will disappear.

    He is looking at using specific immune modulating/suppressing drugs to bring the immune system back into balance.

  7. Cort

    Cort Phoenix Rising Founder

    I asked him about someone who had suffered huge swings in health - from getting much better to falling apart - and he said the prime candidate was natural killer cell functioning.....or rather the failure of the NK cells to keep the pathogens in check.
  8. firefly


  9. Navid

    Navid Senior Member


    is dr. P going to do a trial of cidofovir/visitude (which is given thru IV and FDA approved) or the cmx0001 (which is orally administered and in stage 3 trials)...can you pls clarify. it would be great if a SF bay area doc could do a trial of the cmx0001.....kogelnik?

  10. August59

    August59 Daughters High School Graduation

    Upstate SC, USA
  11. Sasha

    Sasha Fine, thank you

    This is very interesting - I just read the whole SARS quote, which is:

    I hadn't realised Dr Lipkin would be already familiar to some extent with ME in a SARS context and I think it's great that he is. It must be similar in some ways to seeing an ME outbreak like Incline Village or Lyndonville - blindingly clear viral onset and no doubt that there's a serious biological disorder.

    We're really lucky to have him working on this.
  12. *GG*

    *GG* senior member

    Concord, NH
    Is this Dan Peterson of the wPi fame? If yes Cort, have you not met him before?


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