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DIO2 expression levels in peripheral cells are reduced during depression

Discussion in 'Other Health News and Research' started by pattismith, Jul 22, 2018.

  1. pattismith

    pattismith Senior Member

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    Expression levels of interferon-ɣ and type 2 deiodinase in patients diagnosed with recurrent depressive disorders
    2018
    Abstract
    Background
    Thyroid hormones (TH) are involved in modulation of the immune system and inflammation. TH dysregulation is associated with depressive disorders. The iodothyronine deiodinases (DIOs), the key enzymes for TH synthesis, can be affected and induced by pro-inflammatory cytokines. We aimed to investigate the levels of and correlation between type 2 DIO (DIO2) and interferon-gamma (IFN-ɣ) in patients with recurrent depressive disorders (rDD).

    Methods
    Data from 91 rDD patients and 105 healthy controls were analyzed. The diagnoses are based on the ICD-10 criteria (F33.0-F33.8). Expression levels of DIO2 and IFN-ɣ were estimated using the method based on the polymerase chain reaction and the enzyme-linked immunosorbent assay (ELISA).

    Results
    The DIO2 expression on mRNA/protein levels in rDD patients (both female and males) was reduced as compared with the control subjects. No correlation between DIO2 and IFN-ɣ expression was observed.

    Conclusion
    This is the first study to reveal that one may cautiously suggest that DIO2 may be involved in the development and/or progression of rDD. The mechanisms of TH regulation on depression, however, need further investigation.

    https://www.sciencedirect.com/science/article/pii/S1734114017303055
     
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