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Defective T-cell control of EBV infection in multiple sclerosis

Discussion in 'Other Health News and Research' started by pattismith, Jan 17, 2018.

  1. pattismith

    pattismith Senior Member

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    Defective T-cell control of Epstein–Barr virus infection in multiple sclerosis

    Published online 20 January 2017

    Michael P Pender, Peter A Csurhes, Jacqueline M Burrows and Scott R Burrows

    Abstract

    Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in the pathogenesis of multiple sclerosis (MS).

    Defective elimination of EBV-infected B cells by CD8+ T cells might cause MS by allowing EBV-infected autoreactive B cells to accumulate in the brain.

    Here we undertake a comprehensive analysis of the T-cell response to EBV in MS, using flow cytometry and intracellular IFN-γ staining to measure T-cell responses to EBV-infected autologous lymphoblastoid cell lines and pools of human leukocyte antigen (HLA)-class-I-restricted peptides from EBV lytic or latent proteins and cytomegalovirus (CMV), in 95 patients and 56 EBV-seropositive healthy subjects. In 20 HLA-A2+ healthy subjects and 20 HLA-A2+ patients we also analysed CD8+ T cells specific for individual peptides, measured by binding to HLA-peptide complexes and production of IFN-γ, TNF-α and IL-2.

    We found a decreased CD8+ T-cell response to EBV lytic, but not CMV lytic, antigens at the onset of MS and at all subsequent disease stages.

    CD8+ T cells directed against EBV latent antigens were increased but had reduced cytokine polyfunctionality indicating T-cell exhaustion.

    During attacks the EBV-specific CD4+ and CD8+ T-cell populations expanded, with increased functionality of latent-specific CD8+ T cells.

    With increasing disease duration, EBV-specific CD4+ and CD8+ T cells progressively declined, consistent with T-cell exhaustion.

    The anti-EBNA1 IgG titre correlated inversely with the EBV-specific CD8+ T-cell frequency.

    We postulate that defective CD8+ T-cell control of EBV reactivation leads to an expanded population of latently infected cells, including autoreactive B cells.
     
    wastwater, bspg, BadBadBear and 6 others like this.
  2. Tammy

    Tammy Senior Member

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    New Mexico
    I agree................and that's why there are so MANY overlapping symptoms of CFS and MS. With some cases of aggressive MS, I believe it's because of a more aggressive strain of EBV.
     
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  3. raghav

    raghav Senior Member

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    I suffer from hippocampal sclerosis with atrophy. Is it a milder version of MS ? My fatigue started only after this.
     
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  4. ljimbo423

    ljimbo423 Senior Member

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    I think this study shows immune system dysfunction causing high EBV titers, not increased viral load. The PCR testing for viral load is not "statistically significant".

    Jim
     
    Last edited: Jan 18, 2018
    andyguitar likes this.

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