I am being investigated for intermittent but chronic stomach issues/pain over a very long time. I have self treated for years having had gastritis around 10 yrs ago and took PPIs for a couple of years. So far tests have turned up a small hiatus hernia, and a 'fair sized' gallstone, though much of the pain I have had has not been along the lines of normal gallstone pain (except once a couple of months ago when I woke in the night with pain after a meal that was too heavy in fat so have now reduced that). No gastritis or inflammation this time round. Gastro thought I had Non Ulcer Dyspepsia before the tests were done. I am waiting for the gastroenterologist to come back to me, but I also had some blood tests which I asked them to send me. As this is the NHS UK I don't often get blood tests done so I always look to see if there is anything of interest re the ME stuff. As they are not very much below range I am expecting them to do nothing but I wanted to know what a below range result might mean if it continued in that direction. For the past 3 years I have had low platelets below range, but as I had low platelets in pregnancy some 30 yrs ago, I am not surprised by this, and it's supposed to be autoimmune in pregnancy (ITP). The latest one is still below range but no lower than last time The other 2 results that were below range are these.... Low IgA is 0.70 (range 0.8 - 4.0), the IgG and IgM are in normal range. I don't think I have ever had this tested before and I see they did another test due to this (for bone cancer I think) which was negative (I googled it). Liver Function Test and under Globulin on the list also low below range at 19 (range 20 - 35). This is one point lower than about 2 yrs ago which I think is the only time I have had it tested. I did a Google and found this re the IgA ......(I am not taking any of the drugs mentioned) 'Abnormal test results typically indicate that there is something affecting the immune system and suggest the need for further testing. Low levels The most common causes of decreased immunoglobulins are acquired underlying (secondary) conditions that either affect the body's ability to produce immunoglobulins or that increase the loss of protein from the body. Deficiencies may also be due to drugs such as immunosuppressants, corticosteroids, phenytoin, and carbamazepine or due to toxins.' and this below re the low result for Globulin....all looks rather scary, though as my other results are fine hopefully not what it suggests! I cut out gluten from my diet about 3 yrs ago. I eat a v clean diet with virtually no sugar other than a little fruit, low grains, lowish carbs, low fat now! Lots of veg, but I do eat meat/fish etc. 'Low Globulin Levels. Low serum globulin levels typically indicate liver disease, an inability to digest or absorb dietary protein, inflammatory bowel disease or celiac disease, some sort of cancer, hemolytic anemia or kidney disease.'