So my CFS started around 1997. I was in denial for so many years blaming myself for being lazy that I don't really know how it started. One thing that did happen In 1997--I was in Northern Minnesota and Wisconsin for a couple weeks in the deep woods hiking and got a big bullseye rash on my arm. I had heard of Lyme Disease so as soon as I got back to Arizona I went to see my doctor (saw the PA) and she told me she could either test me for Lyme Disease but it takes days or weeks to get results or she could put me on antibiotics right away but then I would not know if I had Lyme because the tests would be false negative after I take the antibiotic (which doesn't make sense now but that is what she told me--maybe it was an insurance thing?). So I chose to go on the antibiotics right away and not get tested. They did take a scrapping of the rash to test for other possibilities like ring worm but they came back negative. I didn't really think about it again for about ten years when I finally started realizing my fatigue was not laziness and started seeing specialists and doing research. Every search for my symptoms would come up with Lyme disease amongst others and I read about Chronic Lyme Disease. I went to a rheumatologist and he dismissed my Lyme concern saying that Lyme wasn't in the areas of Minnesota or Wisconsin that I had been in. He did a Western Blot test anyway and it was negative. Years later I was on the CDC site and saw a link for a Lyme Disease map and the area of Minnesota and Wisconsin I was in came up almost solid red with dots of outbreak areas which made the hairs on my arms stand up, so I went back to the rheum doc and he did another Western Blot and again it was negative. He told me the Western Blot is extremely accurate. Do you think I should give up on the Lyme angle of my CFS? I do get fevers easily and during my last two surgeries I had fevers of 102 and 103 and they could not find a reason. Do you know if that is a Lyme thing, weird fevers when the body is stressed? Normally my temperature runs low. The weird thing is that I was telling my medical oncologist (just had cancer) about my symptoms so she'd know I wasn't a healthy patient she was putting on chemo, and out of the blue she said "It sounds like Lyme Disease". Not something you hear from doctor's in Arizona so it got me thinking again about Lyme. After a surgery in December, I had a fever of 102 so they put me on strong antibiotics and then I caught c.diff from the hospital, ended up with blood sepsis, spent a week in the hospital. Was very ill for 2 1/2 months, so experimenting on antibiotics is not something I want to do without real reason but then again I am desperate to cure my CFS.