Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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CLTA4 Associated with Autoimmune Thyroid Diseases

Discussion in 'Genetic Testing and SNPs' started by Changexpert, Jun 13, 2015.

  1. Changexpert

    Changexpert Senior Member

    For past year, I've tried numerous forms of iodine like generic kelp, Lugol's 2%, modifilan, ecklonia cava extract, potassium iodide, and even nascent iodine. The reason why I took iodine was because I've been suffering from hypothyroidism (sensitive to coldness, low energy, hair loss, brain fog, etc) for years, and it has been only getting worse with recent two major surgeries I had. Also, my urine test showed that I have close to zero level of iodine.

    However, taking iodine, both by ingestion and transdermal absorption (rubbing iodine on the belly) has caused severe side effects. Side effects included increased hair loss, muscle twitching, joint pains, insomnia, and severe brain fog. The extent of side effects was proportional to how much iodine I took. After talking to a few members on the forum, I realized that iodine can induce Hashimoto's or Graves autoimmune disorder for some people.

    I was still not convinced, which is why I took many kinds of iodine available on the market. Regardless of which forms I tried, the side effects came on within a day. I gradually gave in to the fact that iodine is not for me, but still could not figure out why.

    Fortunately, by going through my MTHFR results once again, I finally figured out that CLTA4 genes are associated with autoimmune thyroid diseases. I am heterozygous for many CLTA4 genes and homozygous for one of them. I can finally let go of iodine in peace and may seek for T3 only or dessicated thyroid. I am sure @ahmo would be thrilled to see this post.

    PS: I am not associated with website in any way.

    victoriana and out2lunch like this.
  2. out2lunch

    out2lunch Senior Member

    Thanks for the info about CLTA4! :)

    You and I are cut from the same "troubled iodine" cloth. I was diagnosed with Hashi's almost 20 years ago. While the antibodies now only appear during severe illness or times of extreme stress, they will also appear when I take large doses of iodine. Thyroid tests revealed that my TSH goes up, my T4 goes down along with my T3, without changing my desiccated thyroid dose. Which also translates into worsening hypo symptoms. And stopping the iodine results in the T4 and T3 gradually increasing with TSH decreasing, again without changing dosing.

    From what I've read by knowledgable functional medicine docs, and from my own personal experience with iodine supplementation (even though my levels also test as deficient), taking iodine with Hashi's is hugely problematic. Iodine can suppress the thyroid gland if taken in doses "too high." But where's the divide line for someone with autoimmune thyroiditis? Very small doses seem to be a safer bet.

    FWIW, this is what I take daily, one drop under the tongue:

    Since I started taking this at the beginning of the year, I've had the best thyroid results ever. No more up and down yo-yo TSH/T4/T3, and Reverse T3 isn't sky high like it has been for the past few years. I'm on Acella desiccated thyroid twice a day with one drop of the Thyadine in the morning, and I can finally say my hypo symptoms are now a thing of the past.
    ahmo and Gondwanaland like this.
  3. Gondwanaland

    Gondwanaland Senior Member

    Some people have been turning to compounded T3/T4 (which is what I take) b/c you may not respond well to vit B2 if you don't have T4. +/+MAO-Aers like us need B2.
  4. ahmo

    ahmo Senior Member

    Northcoast NSW, Australia

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