I have had CFS/ME for over 20 years. In that time, I've heard several theories, which I'm sure you are familiar with: Adrenal imbalance Leaky Gut Syndrome Yeast/Candida Virus or Retro-Virus Toxins Immune System Imbalance Nitric Oxide Cycle Hormonal Imbalance And the list of possible causes goes on and on, almost seeming to never end. I recently came across a very plausible theory that I think is very likely to be correct and needs to be researched further. The theory postulates that since there are so many systems of the body that are effected by CFS, the governing mechanism must be the Autonomic Nervous System. It is the imbalance of the ANS, a neurological damage or root cause, that makes all the other systems go out of whack. The ANS controls the adrenals, immune, digestive, and all other systems. This explains why there are so many different paths to getting CFS, and why there are so many treatments that are effective but not curative. In my own experience, this also explains not only all my symptoms, but why taking certain supplements might make things temporarily better but ultimately worse. Basically, certain treatments are helping the immune system but causing the ANS to go further out of balance. I think that research needs to focus on the neurological damage to the ANS. What do you guys think of this theory?