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This is my attempt to give back a little for all the knowledge I've gleaned here, in no way do I want or need sympathy, if this saves someone the same experience that's what I seek.
After much research I started in on high dose MSM for it's reported anti inflammatory properties and most research you find says the LDL 50 is about like tap water. Selling product?
Well after a few weeks of honeymoon where my skin tone was improving and muscles weren't sore after training I thought I'd found nirvana. Then I noticed I was getting a little more edgy and aggressive- sleeping a little less and thought " Hey maybe it's making more T". NOT
Alas I continued at 8G/day divided am/pm I was always having to pee a lot and thought again maybe detox.In hindsight I was acidic and kidneys were trying to help out.
Fast forward 6 months and a pretty serious bacterial infection and some blood work. Liver enzymes came back mildly elevated and serum Ferritin was very high while Ceruloplasm and RBC magnesium were both on the bottom end of the reference--despite supplementation with both.Low ceruloplasm/magnesium really hampers ATP production as does high ferritin levels.
I know someone will say "hey acute phase reaction- that's all" but hsCRP was low and ferritin is still high 9 months later.
Seems all the cysteine and methionine in MSM play a huge role in metallothionine synthesis and actively chelates copper--not good any day! Also as an side if you have a compromised gut biome there is a sulfur loving bacteria that feasts on ---sulfur(34%/MSM) creating H2S which is a toxin. Perhaps raising liver enzymes?
Cutting to the chase and leaving out all the researching and misery I believe large doses of MSM are in no way beneficial and could be very detrimental to long term health. A month or two? Probably no problem- long term no way. As harmless as water, give me a break!
As an aside I theorize the antiinflammatory effect stems from the moving of copper ions into the bloodstream from storage and the elevated ferritin came from the acidifying effect in the gut or suppression of calcium absorption which up regulated Fe absorption.
I have conferred with the best of the best to arrive here and will be starting down the road of phebotomies to lower ferritin to maybe 80-100. The other parameters should fall in line eventually. Perhaps this post will raise awareness to some who are thinking or are presently taking MSM in high dosage.
2MH
After much research I started in on high dose MSM for it's reported anti inflammatory properties and most research you find says the LDL 50 is about like tap water. Selling product?
Well after a few weeks of honeymoon where my skin tone was improving and muscles weren't sore after training I thought I'd found nirvana. Then I noticed I was getting a little more edgy and aggressive- sleeping a little less and thought " Hey maybe it's making more T". NOT
Alas I continued at 8G/day divided am/pm I was always having to pee a lot and thought again maybe detox.In hindsight I was acidic and kidneys were trying to help out.
Fast forward 6 months and a pretty serious bacterial infection and some blood work. Liver enzymes came back mildly elevated and serum Ferritin was very high while Ceruloplasm and RBC magnesium were both on the bottom end of the reference--despite supplementation with both.Low ceruloplasm/magnesium really hampers ATP production as does high ferritin levels.
I know someone will say "hey acute phase reaction- that's all" but hsCRP was low and ferritin is still high 9 months later.
Seems all the cysteine and methionine in MSM play a huge role in metallothionine synthesis and actively chelates copper--not good any day! Also as an side if you have a compromised gut biome there is a sulfur loving bacteria that feasts on ---sulfur(34%/MSM) creating H2S which is a toxin. Perhaps raising liver enzymes?
Cutting to the chase and leaving out all the researching and misery I believe large doses of MSM are in no way beneficial and could be very detrimental to long term health. A month or two? Probably no problem- long term no way. As harmless as water, give me a break!
As an aside I theorize the antiinflammatory effect stems from the moving of copper ions into the bloodstream from storage and the elevated ferritin came from the acidifying effect in the gut or suppression of calcium absorption which up regulated Fe absorption.
I have conferred with the best of the best to arrive here and will be starting down the road of phebotomies to lower ferritin to maybe 80-100. The other parameters should fall in line eventually. Perhaps this post will raise awareness to some who are thinking or are presently taking MSM in high dosage.
2MH