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"ATP as a Biological Hydrotrope" - high cellular concentrations keep protein from aggregating, etc.

Discussion in 'Other Health News and Research' started by ZeroGravitas, Jun 11, 2017.

  1. ZeroGravitas


    From new research - A secondary, and perhaps very important, function of ATP molecules inside cells appears to be preventing (and reversing) protein aggregation, keeping them and other substances in solution.

    Speculation - if pwME/CFS have lower ATP production, and so also lowered concentrations, does this lead to an increase in problems with proteins aggregating inside cells (as happens more often in elderly, e.g. amyloid-beta clumps in neurons with Alzheimer's)? Or are there compensatory mechanisms to compensate, e.g. dumping of proteins and other nutrients from cells? Or is ATP concentration merely preserved inflexibly at the cost of energy use?

    Research paper Abstract published in Science: http://science.sciencemag.org/content/356/6339/753.long
    Via article on The Longevity Reporter (below): http://longevityreporter.org/blog/2017/6/8/why-do-our-cells-contain-so-much-atp
    Starlight and Hutan like this.

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