A New Decade of ME Research: The 11th Invest in ME International ME Conference 2016
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Association of Fatigue With Tryptophan Hydroxylase Genetic Polymorphisms in Women With IBS

Discussion in 'Other Health News and Research' started by Murph, Oct 13, 2018.

  1. Murph

    Murph :)

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    Biol Res Nurs. 2018 Oct 11:1099800418806055. doi: 10.1177/1099800418806055. [Epub ahead of print]
    Association of Fatigue With TPH2 Genetic Polymorphisms in Women With Irritable Bowel Syndrome.
    Han CJ1, Jarrett ME2, Cain KC3, Jun S4, Heitkemper MM2.
    Author information
    1
    1 Department of Public Health, University of Washington & Fred Hutchinson Cancer Research Center, Biobehavioral Cancer Prevention and Control Training Program, Seattle, WA.
    2
    2 Department of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, WA, USA.
    3
    3 Department of Biostatistics and Office of Nursing Research, University of Washington, Seattle, WA, USA.
    4
    4 College of Nursing, Keimyung University, Daegu, South Korea.
    Abstract
    Fatigue is the most common extraintestinal symptom in women with irritable bowel syndrome (IBS). Genetic polymorphisms of monoamines are associated with fatigue in many chronic diseases. In this pilot exploratory study, the primary aim was to determine whether genetic polymorphisms of tryptophan hydroxylase ( TPH1/TPH2), serotonin reuptake transporter ( SERT), or catechol-O-methyltransferase ( COMT) are associated with fatigue in women with IBS. Additionally, analysis explored whether these genetic associations with fatigue would be present when controlling for abdominal pain, psychological distress, feeling stressed, and sleepiness during the day. Secondary analysis of two randomized controlled trial baseline data sets in Caucasian women with IBS ( N = 185) was conducted. Participants kept a daily diary with one dimension (i.e., severity) for each of the 26 symptoms, including fatigue, for 28 days prior to randomization. DNA samples were tested for single-nucleotide polymorphisms (SNPs) of TPH1 (four SNPs) /TPH2 (one SNP), SERT (one SNP), and COMT (one SNP). Analysis of covariance was used to examine associations of percentage of diary days with moderate to very severe symptoms with genetic polymorphisms. Only one SNP, TPH2 rs4570625, was significantly associated with fatigue ( p = .005). T-allele (low functional) carriers of TPH2 (i.e., G/T or T/T genotypes) reported a greater percentage of days with moderate to very severe fatigue than G/G homozygotes ( p = .001). Reduced synthesis of tryptophan in the central nervous system may contribute to reports of fatigue in women with IBS. Understanding genetic risk factors for fatigue may elucidate preemptive strategies to reduce fatigue in individuals with IBS.

    KEYWORDS:
    catechol-O-methyltransferase; fatigue; genetic polymorphisms; irritable bowel syndrome; serotonin reuptake transporter; tryptophan hydroxylase

    PMID:
    30309244
    DOI:
    10.1177/1099800418806055
     
  2. Murph

    Murph :)

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    Thought this one was interesting in the light of the recent theories by Dr Robert Phair on a possible gentic dysfunction leaving ME/CFS patients with high Tryptophan levels.

    This enzyme is related to breaking trp down into serotonin though, different to the one Phair has identiifed that breaks trp into kynurenine.
     

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