Choline on the Brain? A Guide to Choline in Chronic Fatigue Syndrome
http://phoenixrising.me/research-2/the-brain-in-chronic-fatigue-syndrome-mecfs/choline-on-the-brain-a-guide-to-choline-in-chronic-fatigue-syndrome-by-cort-johnson-aug-2005
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Anyone else have rs880844 AA?

Discussion in 'Genetic Testing and SNPs' started by Kimsie, Dec 9, 2014.

  1. Kimsie

    Kimsie Senior Member

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  2. Critterina

    Critterina Senior Member

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    Arizona, USA
    Nope, I've got the GG.
     
  3. halcyon

    halcyon Senior Member

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    AG here. Not seeing a lot about it on Google. What's your interest in it?
     
  4. Valentijn

    Valentijn Senior Member

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    It doesn't mean anything just because it's less frequent. And in the case of that SNP, the AA genotype is still extremely common (up to 30% in some populations), just slightly less common than GG or AG. It also doesn't have any known mutation in the protein associated with it, nor any research showing that it's a problem.
     
  5. Kimsie

    Kimsie Senior Member

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    I see. On opensnp it was 5%, but that is probably not a very large sample.

    Halcyon, I was asking because I think there could be something going wrong with the iron-sulfur clusters, which would cause the electron transport chain to be inhibited, but there wouldn't necessarily have to be a mutation for that to happen.

    I think the electron transport chain must to be inhibited in these illnesses, and I was wondering if there are some people who are more susceptible to inhibition of the ETC by interference with iron-sulfur clusters (by H2O2, i.e. oxidative stress) than other people.
     
    halcyon likes this.

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