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Alem Matthees analyses on released PACE data blast "recovery" claims - huge damage to PACE

Discussion in 'Latest ME/CFS Research' started by user9876, Sep 21, 2016.

  1. user9876

    user9876 Senior Member

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    There is a new article on virology covering the re-analysis of PACE data

    http://www.virology.ws/2016/09/21/no-recovery-in-pace-trial-new-analysis-finds/

     
    Last edited: Sep 21, 2016
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  2. Simon

    Simon

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  3. Simon

    Simon

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    Julie Rehmeyer's piece at Stat



     
    Last edited: Sep 21, 2016
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  4. user9876

    user9876 Senior Member

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    As well as Alem and other patients this analysis is co-authored by 2 statistics professors

    Philip Stark - Associate Dean, Mathematical and Physical Sciences; Professor, Department of Statistics; University of California, Berkeley, California, USA.
    Bruce Levin - Professor of Biostatistics and Past Chair, Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, USA
     
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  5. Valentijn

    Valentijn Senior Member

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    :rofl:
     
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  6. sarah darwins

    sarah darwins I told you I was ill

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    Leslie Nielsen Nothing to See Here.jpg

    "MOVE ALONG, FOLKS. NOTHING TO SEE HERE"
     
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  7. Sidereal

    Sidereal Senior Member

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    Looks like the talking point by the Wessely school is going to be "the primary outcome of improvement was still statistically significant", neglecting to mention that the improvement rate plummeted from 60% in the Lancet to now 20%, only a 10% difference between SMC vs CBT/GET. Nothing to see here, indeed.
     
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  8. user9876

    user9876 Senior Member

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    But it was small and not backed up by objective measures. It would be shocking if it wasn't in a trial where you ask people how they feel, tell them they will recover if the feel different and ask them how they feel.
     
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  9. A.B.

    A.B. Senior Member

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    The "medical care" may have been as little as 3 sessions of 30 minutes each over the course of a year.

    Source http://www.margaretwilliams.me/2016/proof-positive-revisited.pdf

    I also recall a comment on social media from a person claiming to be a PACE trial participant, sayin that she was in the "medical care" arm and never received any care at all.
     
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  10. worldbackwards

    worldbackwards A unique snowflake

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    A personal favourite

     
  11. AndyPR

    AndyPR Senior Member

    Awesome work @Tom Kindlon , thank you so much, you and all the authors. :thumbsup:
     
  12. ClarkEllis

    ClarkEllis

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  13. Sidereal

    Sidereal Senior Member

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    Are there any data in their published papers on what SMC actually involved? In the real world, I mean, not in theory.
     
  14. Sam Carter

    Sam Carter Guest

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    Huge thank you to everyone involved in this. No wonder PDW retired ....

    For anyone trying to replicate the analysis I thought I'd point out that the hash value for the excel file given in the accompanying notes is actually a SHA-1 checksum and not a SHA-256 value as stated.
     
  15. A.B.

    A.B. Senior Member

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    PACE authors will still try to spin these pathetic results as success, failing to acknowledge the problems of lack of blinding and the Oxford criteria.
     
  16. worldbackwards

    worldbackwards A unique snowflake

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    Can really 6% vs 3% be spun in any language? It's nothing.
     
  17. adreno

    adreno PR activist

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    The analysis has to come from someone with authority, or it won't matter. Sadly.
     
  18. Simon

    Simon

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  19. AndyPR

    AndyPR Senior Member

    Did you not spot who all of the authors where?
    At the very least those last two look reasonably authoritative to me, with no insult meant to the other authors.
     
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  20. Amused

    Amused

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    I was on the Trial CBT. I asked for the SMC several times cos I wanted to discuss things like symptoms I had and how to deal with them like pain. Never got it. Ended up thinking the signoff to the Trial session was the SMC, it wasn't. The person running that session was the SMC person so tried to help but it was a bit of a muddle. Bascially he said 'try to take fewer pain killers' in response to my 'why aren't the pain killers working? is the pain real? are they the wrong ones? (basic paracetamol).

    Oh I also got given a book before I went on the Trial that the Centre Director said SMC people were given.

    So as far as I can see SMC was pretty much 'real world' in that no-one bloody listened or had any useful input! Not sure what was supposed to happen though.
     
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