I just got my 23andMe results back and am slowly working my way through Heartfixer.com, Dr Lynch's site and every other thread in this forum. In the mean time I would really appreciate any input I can get on these. But first some background... Chronic Fatigue Moderate depression (Prozac has made a BIG difference) Hypothyroidism (Elevated RT3/Low Free T3) -Now self medicate 100mcg T3 per day yet I can double my dose and it has no physical affects. Brain fog (noticeably less intelligent than I used to be) Eat a pretty lowcarb/high fat/high protein diet Supplements - Daily B-Complex (stopped) COQ 10 2-400mg D3 10,000iu Chromium 200mcg Magnesium 400mg Zinc 30mg Methylfolate 800mcg (just started a week ago) TMG ~5g per day NAC ~5g per day Glutamine 10g per day Curcumin w/ Bioperine 1g/5mg 2x per day Report Generated by GeneticGenie: Homozygus Mutations VDR Taq MAO-A R297R Heterozygous Mutations: MTHFR C677T MTHFR 03 P39P MTHFR A1298C COMT V158M COMT H62H MTRR A66G MTRR A664A BHMT-02 BHMT-08 Again, any help would be highly appreciated and thank you in advance!