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23and ME Vs others Genetic testing

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by lnester7, Nov 23, 2013.

  1. lnester7

    lnester7 Seven

    I am looking into getting my methilation and detox genes tested, I want to know which one is the best to get done and the most complete analysis, I can afford it so price is not an issue (within reason), I prefer to have it as complete as possible.

    rosie26 likes this.
  2. minkeygirl

    minkeygirl But I Look So Good.

    Left Coast
    I don't know about anything besides 23andMe but I know with that there are 2 places where you can go to get the raw data put into numbers. One is genetic genie and the other, which I think is considerable more comprehensive is

    Maybe you can email them and ask what you get with them?
    lnester7 likes this.
  3. Sea

    Sea Senior Member

    NSW Australia
    23andme test for more than 900 000 snps for $99 and give lots of information about various health risks. They don't analyse your methylation or detox pathways but this information is easy to find from your raw data using:
    Genetic Genie (free or donation of $10 for methylation & $5 for detox) then reading Heartfixer or Yasko for what to do with your info
    MTHFRsupport ($20 methylation, detox and more) includes report
    Livewello (I think also $20, and I think they got their info from MTHFRsupport) includes report

    ...or for free you can even look up your snps from your raw data yourself and organise them into some sort of spreadsheet. You'll find yourself doing that as more information becomes available than what the different groups offer anyway and you realise what a wealth of information is available in your raw data.

    The other option is Yasko for hundreds of dollars who tests only around 30 snps of the methylation pathway. She does have a couple of snps that 23andme don't have, but I don't think they are vital. She also includes a report
    Valentijn likes this.
  4. Valentijn

    Valentijn Senior Member

    23andMe is the best value for the money. $99 for 960,000 SNPs, versus $495 from Yasko for a few dozen. In addition, the few which Yasko tests that aren't in 23andMe are mostly irrelevant anyhow.

    As listed above, there's plenty of places to process 23andMe results. I also have a downloadable program at which can let you pull out your extremely rare SNPs, in case there's anything of interest in there.

    I doubt methylation is a huge factor in ME/CFS (though it does make a difference), so it makes sense to do broader testing.
  5. JohnnyD

    JohnnyD Senior Member

    This might deserve it's own topic since so many here have used the 23andme testing

    Stop selling those DNA tests, FDA tells 23andMe
    Maggie Fox NBC News
    55 minutes ago

    The Food and Drug Administration has ordered DNA testing company 23andMe to stop marketing its over-the-counter genetic test, saying it’s being sold illegally to diagnose diseases, and with no proof it actually works.

    The heavily marketed test includes a kit for sampling saliva, and the company promises to offer specific health advice. “Based on your DNA, we’ll provide specific health recommendations for you,” the company says on its website. "Get personalized recommendations."

    In an unusually scathing letter dated Friday, the FDA says it’s been trying to work with the company to get some sort of evidence that the test can do that with any accuracy.
  6. Valentijn

    Valentijn Senior Member

    Odd. Maybe the FDA doesn't know that there are SNPs proven to be pathogenic?
  7. August59

    August59 Daughters High School Graduation

    Upstate SC, USA
    I think Genova Diagnostics does them, but you have to get a doctor to order it and it is pretty expensive too, I believe.
  8. Gloria H

    Gloria H

    South Dakota
    @Valentijn I couldn't figure out what to do with the Sourceforge program when I opened it. What type file does it want from the 23andme folder? Are there detailed instructions for using Sourceforge somewhere?
    Blessings to you!
  9. Valentijn

    Valentijn Senior Member

    45,897 has step-by-step instructions. It wants your unzipped 23andMe file, plus a database file (the 1% database gets automatically selected for you).

    There can be issues with using the program on some Macs, probably due to a publisher ID needed - we'll fix that one of these days :p
    Gloria H likes this.

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