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worst symptoms occur at 3-4am . . . . . wake up abruptly and feel terrible . . . . . any suggestions on how to treat the adrenaline filled wake ups that leave me feeling so ill . . . . feels like it is hormonal yet all my tests are normal (of course). This sounds so familiar to me. For the past...

"The vast array of dysfunction and dysregulation strongly imply an ongoing process, one that is likely self perpetuating". Self perpetuating - exactly. An initiating trigger event, either sudden or cumulative, disrupts the hypothalmic-pituitary-adrenal axis, creating a dysfunctional state...

At night I take: 1. Gabapentin 300 mg 2. Zolpidem 15 mg 3. Magnesium Sulfate injection 2 ml plus: 4. NAC 1000 mg 5. D-Ribose 4-5 g in warm milk The NAC and D-Ribose make little perceivable impact, although I think they help a bit. This is where I am just now and it's the best combo I've had...

Hi Redrachel I've had ME/CFS for 14 years and have been persistently affected by gastric problems, primarily what could be described as IBS. I think that Sarah Myhill's (and other's) hypothosis that so many of the symptoms overall can be explained by mitochondrial failure is absolutely robust...