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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. Paula Thomas

    MTHFS defect (folinic acid intolerance) - request for genetic data

    I use Holistic Health drops B12: 2000mcg and (6S)-5-Methyltetrahydrofolic acid 66.7mcg. That's 1 drop each in the morning sublingually.
  2. Paula Thomas

    MTHFS defect (folinic acid intolerance) - request for genetic data

    Could be the increase in B12. Hydroxy B12 made me have fatigue so I've been taking Adenosyl B12 instead and I seem to tolerate that better.
  3. Paula Thomas

    MTHFS defect (folinic acid intolerance) - request for genetic data

    Folic Acid, Folinic Acid, Folate, it's hard to keep them all straight. :) I have eliminated all my supplements that contain folic acid already and only use the good ones that have 5-MTHF or L-Methylfolate. I'm not sure about folinic acid, I don't think I've tried taking that.
  4. Paula Thomas

    MTHFS defect (folinic acid intolerance) - request for genetic data

    Not sure if anyone is still looking into this but thought I'd add mine in. I don't know if I really have any negative affects from Folic Acid. I've never taken it in high doses but my serum folate levels have always been high which makes me think I have a hard time converting it. Rich=1...