Also of interest is that the fluctuating CRP values aren't necessarily elevated out of a normal range at any point. He proposes that this could be due to a low-level biological infection and/or an infection trying to emerge.
More specifically with regards to fractalkine, he says it's elevated in a lot of autoimmune and chronic inflammatory disorders where there isn't an infection.
He's still analyzing the group which has neither the CRP nor the fractalkine tracking with their fatigue symptoms, to look for identifying characteristics. Their symptoms might be related to different immune markers, or driven by energy metabolism, endocrine disregulation, etc, instead of the immune system.
He's just started digging into this data, and is definitely going to follow up on it. He hopes they can develop some objective tests to distinguish between subtypes to use more targeted treatments.
For the CRP group, they need to start looking for viruses and bacteria, and any fluctuations of those.
They're starting with a large new cohort to see if these results replicate.
He can't give more information, due to upcoming publication in a scientific journal. But he'll continue giving us updates with little peeks into what's going on.