EBV IgG reactive
Autoantibody screen showed positive nuclear antibody with homogenous HEp2 pattern.
Outranged serum lipids.
ALT been high then normal.
Low vit D.
Ccp antibody weakly positive.
IgM slightly raised.
High rheumatoid factor.
3/4 brain lesions.
Chilblains.
Saw 2 rheumatologists who say i don't have Rheumatoid arthritis or lupus. Saw a neurologist who did a lumbar puncture and evoke potential test for ms and both were negative. Been ill 14yrs.
A clinical diagnosis of something like lupus or RA in theory has to include some sort of clinical features like rash or joint swelling etc. So strictly speaking in terms of 'diagnostic criteria' you probably do not have lupus or RA. However, as has been discussed on the forum before diagnostic criteria of this sort are not necessarily very helpful in real life.
You clearly have an autoimmune process going on - you have antinuclear antibodies, rheumatoid factors and maybe anti-ccp. That process looks to be heading in a direction most like lupus, although the titre of the antinuclear antibody would be important here. Homogeneous staining of Hep2 cells if pretty specific for lupus but only if the titre is above a minimum background (often 1/10-1/20). Chilblains are also more associated with lupus type autoimmunity than RA-type.
The problem is that there are a lot of people on the borderline of these sorts of illness. There are also a lot of people who have the antibodies who have an increased chance of going on to get an overt illness and also people with the antibodies who remain well. My feeling is that there are two important questions that may be more helpful than 'do I have lupus'. One is whether you are feeling unwell because of an autoimmune process that is roughly of a lupus type. That is very hard to answer but in this situation in my own practice I always thought that it was plausible to think that might be the case. The other question is whether you are likely to develop other features of lupus later. The answer must be yes, because we know this from long term studies, but the chance may be low if nothing more overt has occurred over 14 years.
I personally suspect that testing for Lyme may be a red herring here. If you have raised IgM and antinuclear antibodies you may find you have raised levels of antibody to all sorts of things as an artefact of an autoimmune process (lupus patients can have antibodies to all sorts of things they have never come across).
As mentioned by others it would be important to make sure you have seen a rheumatologist with a good grounding in immunology rather than someone who applies diagnostic criteria on a rubber stamp basis. If it is of help you could send me a personal message indicating what city you are near and I may be able to advise on the relevant specialist.
In simple terms I would say that someone with homogeneous ANA on Hep2 (of significant titre), rheumatoid factor and maybe anti-ccp with inappropriate chilblains (i.e. not due to being frozen) could be expected to very likely have significant fatigue and other general symptoms as part of that type of autoimmunity. I would probably not look for another diagnosis but I am not in charge of your case and what you need is to get a balanced opinion from someone actually looking after you.