Hello,
This is my first post, though I've been reading up around this site trying to understand all of this genetic info better, especially as it pertains to CFS and thyroid & adrenal dysfunction. I've been doing ongoing research over the last 3 1/2 yrs for my now 20 yo daughter in attempt to figure out the cause of her declining health. After multiple doctors and tests we recently got back 23andMe results and ran them through Gentic Genie, Nutrahacker, and Yasko's reader. I need someone to direct me to other posts/ sites/ MD's/ etc, to see if these results may be contributing to her deteriorating health issues or if I should look elsewhere, AND what to do about it.
METHYLATION
PATHWAYS
COMT V158Mrs4680AG+/-
COMT H62Hrs4633CT+/-
COMT P199Prs769224GG-/-
VDR Bsmrs1544410CC-/-
VDR Taqrs731236AA+/+
MAO A R297Rrs6323GG-/-
ACAT1-02rs3741049GG-/-
MTHFR C677Trs1801133GG-/-
MTHFR 03 P39Prs2066470GG-/-
MTHFR A1298Crs1801131GT+/-
MTHFD1 G1958A
MTHFS
MTR A2756Grs2236225
rs6495446
rs1805087AA
C
AA+/+
+/+
-/-
MTRR A66Grs1801394AA-/-
MTRR H595Ynot foundn/an/a
MTRR K350Ars162036AA-/-
MTRR R415Tnot foundn/an/a
MTRR A664Ars1802059AG+/-
BHMT-02rs567754CT+/-
BHMT-04not foundn/an/a
BHMT-08rs651852CT+/-
AHCY-01rs819147TT-/-
AHCY-02not foundn/an/a
AHCY-19rs819171TT-/-
CBS C699Trs234706GG-/-
CBS A360Ars1801181AA+/+
CBS N212Nnot found
n/an/a
SHMT1 C1420Tnot foundn/a
n/a
DETOX PATHWAYS
CYP1A1*2C A4889Grs1048943TT-/-
CYP1A1 m3 T3205Crs4986883TT-/-
CYP1A1 C2453Ars1799814GG-/-
CYP1A2 164A>Crs762551AC+/-
CYP1B1 L432Vrs1056836GG+/+
CYP1B1 N453Srs1800440TT-/-
CYP1B1 R48Grs10012CC+/+
CYP2A6*2 1799T>Ars1801272AA-/-
CYP2A6*20rs28399444 II-/-
CYP2C9*2 C430Trs1799853CC-/-
CYP2C9*3 A1075Crs1057910AA-/-
CYP2C19*17rs12248560CC-/-
CYP2D6 S486Trs1135840CC-/-
CYP2D6 100C>Trs1065852GG-/-
CYP2D6 2850C>Trs16947GG-/-
CYP2E1*1B 9896C>Grs2070676CG+/-
CYP2E1*1B 10023G>Ars55897648GG-/-
CYP2E1*4 4768G>Ars6413419GG-/-
CYP3A4*1Brs2740574TT-/-
CYP3A4*2 S222Prs55785340AA-/-
CYP3A4*3 M445Trs4986910AA-/-
CYP3A4*16 T185Srs12721627GG-/-
GSTP1 I105Vrs1695AA-/-
GSTP1 A114Vrs1138272CC-/-
SOD2 A16Vrs4880GG+/+
NAT1 R187Qrs4986782GG-/-
NAT1 R64Wrs1805158CC-/-
NAT2 I114Trs1801280CT+/-
NAT2 R197Qrs1799930GG-/-
NAT2 G286Ers1799931GG-/-
NAT2 R64Qrs1801279GG-/-
NAT2 K268Rrs1208GG+/+
I've been reading posts here and from heartfixer, Yasko, mthfrease, MTHFR.net since getting these results. I see the words and am beginning to understand the terminology associated with all of this, but I don't know what to do with it all. I've searched all the sites I can find and haven't found any health care provider that is familiar with these sorts of problems. I understand there may be a need to start in one place and move to another with diet, supplementation, etc. - but we've tried many different things with the promise that it should help, only for her to end up feeling no different at best and being put on the couch not being able to do anything at worst. So, we're hesitant to do much more without knowledgeable direction. I apologize if I've given too much info, but if anyone needs more to help make sense of all of this, I'd be glad to give it if I can.
She's presently diagnosed with being hypothyroid, hypoadrenal (on meds for these) and something's not working right w/ pituitary; Raynaud's and APS (on baby ASA); she's anemic and low ferritin (though has periods of high iron saturation); low Vit D, low Vit B12, low zinc; been told she has CFS (as she meets the criteria), but I'm not sure if it's that, under treated thyroid/ adrenal, something genetic, or some combination thereof that's taking away her health.
Also, what does the "n/a" mean? And, if it means the gene is not present, does that have any implications? I don't understand the "II" either. In addition, the MTHFD1 and MTHFS were not part of the Genic Genie results, but were identified from other gene readers as being significant. Finally, there were plenty of other genes that came up heterozygous, but I don't know of their significanceCETP, FII, F7, F9, FOLR2, DAO, FUT2, GAD1, FD1L, NOS2, NOS3, PEMT, SHMT2, TYMS; CTLA4, FOXE1, NDUFS7, NDUFS8, APOE, TNF, SULT1A1, & SULT2A1)
You all are such a wealth of information, I'd be grateful for any feedback/ input/ direction. Thanks in advance for any and all help -
Lanne P
This is my first post, though I've been reading up around this site trying to understand all of this genetic info better, especially as it pertains to CFS and thyroid & adrenal dysfunction. I've been doing ongoing research over the last 3 1/2 yrs for my now 20 yo daughter in attempt to figure out the cause of her declining health. After multiple doctors and tests we recently got back 23andMe results and ran them through Gentic Genie, Nutrahacker, and Yasko's reader. I need someone to direct me to other posts/ sites/ MD's/ etc, to see if these results may be contributing to her deteriorating health issues or if I should look elsewhere, AND what to do about it.
METHYLATION
PATHWAYS
COMT V158Mrs4680AG+/-
COMT H62Hrs4633CT+/-
COMT P199Prs769224GG-/-
VDR Bsmrs1544410CC-/-
VDR Taqrs731236AA+/+
MAO A R297Rrs6323GG-/-
ACAT1-02rs3741049GG-/-
MTHFR C677Trs1801133GG-/-
MTHFR 03 P39Prs2066470GG-/-
MTHFR A1298Crs1801131GT+/-
MTHFD1 G1958A
MTHFS
MTR A2756Grs2236225
rs6495446
rs1805087AA
C
AA+/+
+/+
-/-
MTRR A66Grs1801394AA-/-
MTRR H595Ynot foundn/an/a
MTRR K350Ars162036AA-/-
MTRR R415Tnot foundn/an/a
MTRR A664Ars1802059AG+/-
BHMT-02rs567754CT+/-
BHMT-04not foundn/an/a
BHMT-08rs651852CT+/-
AHCY-01rs819147TT-/-
AHCY-02not foundn/an/a
AHCY-19rs819171TT-/-
CBS C699Trs234706GG-/-
CBS A360Ars1801181AA+/+
CBS N212Nnot found
n/an/a
SHMT1 C1420Tnot foundn/a
n/a
DETOX PATHWAYS
CYP1A1*2C A4889Grs1048943TT-/-
CYP1A1 m3 T3205Crs4986883TT-/-
CYP1A1 C2453Ars1799814GG-/-
CYP1A2 164A>Crs762551AC+/-
CYP1B1 L432Vrs1056836GG+/+
CYP1B1 N453Srs1800440TT-/-
CYP1B1 R48Grs10012CC+/+
CYP2A6*2 1799T>Ars1801272AA-/-
CYP2A6*20rs28399444 II-/-
CYP2C9*2 C430Trs1799853CC-/-
CYP2C9*3 A1075Crs1057910AA-/-
CYP2C19*17rs12248560CC-/-
CYP2D6 S486Trs1135840CC-/-
CYP2D6 100C>Trs1065852GG-/-
CYP2D6 2850C>Trs16947GG-/-
CYP2E1*1B 9896C>Grs2070676CG+/-
CYP2E1*1B 10023G>Ars55897648GG-/-
CYP2E1*4 4768G>Ars6413419GG-/-
CYP3A4*1Brs2740574TT-/-
CYP3A4*2 S222Prs55785340AA-/-
CYP3A4*3 M445Trs4986910AA-/-
CYP3A4*16 T185Srs12721627GG-/-
GSTP1 I105Vrs1695AA-/-
GSTP1 A114Vrs1138272CC-/-
SOD2 A16Vrs4880GG+/+
NAT1 R187Qrs4986782GG-/-
NAT1 R64Wrs1805158CC-/-
NAT2 I114Trs1801280CT+/-
NAT2 R197Qrs1799930GG-/-
NAT2 G286Ers1799931GG-/-
NAT2 R64Qrs1801279GG-/-
NAT2 K268Rrs1208GG+/+
I've been reading posts here and from heartfixer, Yasko, mthfrease, MTHFR.net since getting these results. I see the words and am beginning to understand the terminology associated with all of this, but I don't know what to do with it all. I've searched all the sites I can find and haven't found any health care provider that is familiar with these sorts of problems. I understand there may be a need to start in one place and move to another with diet, supplementation, etc. - but we've tried many different things with the promise that it should help, only for her to end up feeling no different at best and being put on the couch not being able to do anything at worst. So, we're hesitant to do much more without knowledgeable direction. I apologize if I've given too much info, but if anyone needs more to help make sense of all of this, I'd be glad to give it if I can.
She's presently diagnosed with being hypothyroid, hypoadrenal (on meds for these) and something's not working right w/ pituitary; Raynaud's and APS (on baby ASA); she's anemic and low ferritin (though has periods of high iron saturation); low Vit D, low Vit B12, low zinc; been told she has CFS (as she meets the criteria), but I'm not sure if it's that, under treated thyroid/ adrenal, something genetic, or some combination thereof that's taking away her health.
Also, what does the "n/a" mean? And, if it means the gene is not present, does that have any implications? I don't understand the "II" either. In addition, the MTHFD1 and MTHFS were not part of the Genic Genie results, but were identified from other gene readers as being significant. Finally, there were plenty of other genes that came up heterozygous, but I don't know of their significanceCETP, FII, F7, F9, FOLR2, DAO, FUT2, GAD1, FD1L, NOS2, NOS3, PEMT, SHMT2, TYMS; CTLA4, FOXE1, NDUFS7, NDUFS8, APOE, TNF, SULT1A1, & SULT2A1)
You all are such a wealth of information, I'd be grateful for any feedback/ input/ direction. Thanks in advance for any and all help -
Lanne P