My girlfriends sons results

[zenmaster]

Hoping to find out what supplements will help him, as a side note and may or may not be related to these genes, he does suffer from ADHD. I have seen some links to COMT / MAO mutations being involved in this.

Methylation
COMT V158M rs4680 AA +/+
COMT H62H rs4633 TT +/+
VDR Taq rs731236 AA +/+
MAO A R297R rs6323 T +/+
MTHFR 03 P39P rs2066470 AG +/-
MTHFR A1298C rs1801131 GG +/+
CBS C699T rs234706 AG +/-

Detox
CYP1B1 L432V rs1056836 GG +/+
CYP1B1 N453S rs1800440 CT +/-
CYP1B1 R48G rs10012 CG +/-
CYP2D6 S486T rs1135840 CG +/-
CYP2D6 100C>T rs1065852 AG +/-
GSTP1 I105V rs1695 GG +/+
GSTP1 A114V rs1138272 CT +/-
SOD2 A16V rs4880 GG +/+
NAT2 I114T rs1801280 CT +/-
NAT2 K268R rs1208 GG +/+

 

[Soundthealarm21]

What's his diet like?

 

[zenmaster]

He is a vegetarian 13 year old so eats bread products (pizza, grilled cheese, etc), dairy (especially cheese), vegetables and fruit. Not a lot of processed foods and mostly organic.

 

[Soundthealarm21]

What are his symptoms?

It's possible he has a gluten intolerance. Gluten is known to be a cause of ADHD. What are his other symptoms?

 

[Valentijn]

He is a vegetarian 13 year old so eats bread products (pizza, grilled cheese, etc), dairy (especially cheese), vegetables and fruit. Not a lot of processed foods and mostly organic.

Does he get B12 supplementation? A vegetarian diet would be pretty low in that, as it's only naturally found in meats.

 

[zenmaster]

When he was very young, she tried a gluten free diet with him but it did not seem to have much impact. We have not tried the gluten free diet with him recently. Other symptoms include sensory sensitivity, anxiety, bipolar, and borderline aspergers.

Valentijn -

Considering his mutations, what form of B12 might work best for him?

Thanks!

 

[Critterina]

ADHD seems most related to MTHFR A1298C rs1801131 GG +/+ (as is autism, bipolar, OCD, migraines...a long list). Supplementation with methylfolate might help. Many on this site say it's good to have some B12 when you use methylfolate, although I'd be more concerned if he had the MTRR A66G SNP. Supplementation with Vitamin D may also make a difference.

 

[Valentijn]

Considering his mutations, what form of B12 might work best for him?

He's got the slow version of some SNPs associated with using up methyl groups, so he might have trouble tolerating the additional methyl groups from methylB12. Hence hydroxoB12 would probably be the safer one to try.

 

[zenmaster]

Thanks for the info!