Simon
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A new paper from Griffith University finds immune differences between healthy controls and Me/CFS patients, and correlations between physical status and a few immune markers in ICC ME patients (ie the more physical problems, the stronger the differences in immune markers).
Immune Abnormalities in Patients Meeting New Diagnostic Criteria for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
Brenu EW1,2*, Johnston S1,2, Hardcastle SL1,2, Huth TK1,2, Fuller K1,2, Ramos SB1,2, Staines DR2,3 and Marshall-Gradisnik SM1,2
Free full text (Open Access) pdf available here, but as yet not showing on the journal website. Official link (when live)
(Edit by Snow Leopard) PDF is here:
http://www.omicsonline.org/immune-a...algic-encephalomyelitis-2155-9929.1000152.pdf
Note that the sampe size is rather small: 18 ICC ME patients, 17 CDC-94 (Fukuda) patients and 22 healthy controls. Also Fukuda & ICC were diagnosed by questionnaire, not physician examination and tests, but patients already had an ME/CFS diagnosis (details of how orginally diagnosed not given); 5 patients originally diagnosed with mecfs did not meet either criteria.
Abstract
Background: Immunological abnormalities have been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients fulfilling the 1994 Centers for Disease Control diagnostic criteria [aka Fukuda].
Significant developments have been made to diagnostic criteria, but potential immunological markers have not been assessed in patients fulfilling these latest clinical requirements. Therefore, this study evaluated immunological parameters in patients that also fulfill the latest diagnostic criteria available known as the International Consensus Criteria.
Methods: The Immunological investigations including Natural Killer cell activity and phenotyping studies for dendritic cells [antigen-presenting], neutrophils, B cells and regulatory T cells were performed on whole blood samples collected from all participants using flow cytometric protocols.
The physical functioning of all participants was also evaluated using scores from the Short Form Health Survey, and the World Health Organization Disability Adjustment Schedule.
Results were compared according 1994 Centers of Disease Control and Prevention defined patients, and International Consensus Criteria defined patients, and healthy controls.
Results: Natural killer cell activity was consistently and significantly decreased, and regulatory T cells were significantly increased in both patient groups compared to healthy controls.
Differences were found in human neutraphil antigens and expression of natural killer cell receptors between patient groups.
Highly significant correlations were also found between physical status and some immune parameters in International Consensus Criteria defined patients.
Conclusion: This preliminary investigation on different diagnostic criteria suggests that the ICC may be more effective a detecting salient differences in the immune system.
Immune Abnormalities in Patients Meeting New Diagnostic Criteria for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
Brenu EW1,2*, Johnston S1,2, Hardcastle SL1,2, Huth TK1,2, Fuller K1,2, Ramos SB1,2, Staines DR2,3 and Marshall-Gradisnik SM1,2
Free full text (Open Access) pdf available here, but as yet not showing on the journal website. Official link (when live)
(Edit by Snow Leopard) PDF is here:
http://www.omicsonline.org/immune-a...algic-encephalomyelitis-2155-9929.1000152.pdf
Note that the sampe size is rather small: 18 ICC ME patients, 17 CDC-94 (Fukuda) patients and 22 healthy controls. Also Fukuda & ICC were diagnosed by questionnaire, not physician examination and tests, but patients already had an ME/CFS diagnosis (details of how orginally diagnosed not given); 5 patients originally diagnosed with mecfs did not meet either criteria.
Abstract
Background: Immunological abnormalities have been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients fulfilling the 1994 Centers for Disease Control diagnostic criteria [aka Fukuda].
Significant developments have been made to diagnostic criteria, but potential immunological markers have not been assessed in patients fulfilling these latest clinical requirements. Therefore, this study evaluated immunological parameters in patients that also fulfill the latest diagnostic criteria available known as the International Consensus Criteria.
Methods: The Immunological investigations including Natural Killer cell activity and phenotyping studies for dendritic cells [antigen-presenting], neutrophils, B cells and regulatory T cells were performed on whole blood samples collected from all participants using flow cytometric protocols.
The physical functioning of all participants was also evaluated using scores from the Short Form Health Survey, and the World Health Organization Disability Adjustment Schedule.
Results were compared according 1994 Centers of Disease Control and Prevention defined patients, and International Consensus Criteria defined patients, and healthy controls.
Results: Natural killer cell activity was consistently and significantly decreased, and regulatory T cells were significantly increased in both patient groups compared to healthy controls.
Differences were found in human neutraphil antigens and expression of natural killer cell receptors between patient groups.
Highly significant correlations were also found between physical status and some immune parameters in International Consensus Criteria defined patients.
Conclusion: This preliminary investigation on different diagnostic criteria suggests that the ICC may be more effective a detecting salient differences in the immune system.
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