Daffodil
Senior Member
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for those of us who got CFS after EBV......i was reading about "chronic EBV infection" and came across some articles saying that Hydroxyurea can induce the lytic cycle of EBV. They use it some some EBV-induced cancers cuz antivirals do not work on those...they are caused by the EBV Latent Membrane Proteins.
Lets say our disease is also similar to an EBV-like cancer and the latent proteins are to blame.....what if we were to take hydroxyurea WITH some antivirals? Maybe that would cause eradication or near-eradication of latent EBV by activating the latent EBV and letting the antivirals kill it off...?
They eradicated EBV in a cell liine with hydroxyurea here:
http://www.ncbi.nlm.nih.gov/pubmed/9593003
I also came across an article about a man in Germany who went to see a doc after very recently being infected with HIV (he had a "flu"). The doc gave him HAART + Hydroxyurea (ha! the Germans will do anything). I guess he must have had a very low latent reservoir at that point, because 5 weeks later, he stopped all meds and remained in remission.
They give people with sickle cell anemia Hydroxyurea so maybe it is doable???
There is also Gemcitabine which induces lytic cycle.....cuz EBV can become resistant to Hydroxyurea.
Lets say our disease is also similar to an EBV-like cancer and the latent proteins are to blame.....what if we were to take hydroxyurea WITH some antivirals? Maybe that would cause eradication or near-eradication of latent EBV by activating the latent EBV and letting the antivirals kill it off...?
They eradicated EBV in a cell liine with hydroxyurea here:
http://www.ncbi.nlm.nih.gov/pubmed/9593003
I also came across an article about a man in Germany who went to see a doc after very recently being infected with HIV (he had a "flu"). The doc gave him HAART + Hydroxyurea (ha! the Germans will do anything). I guess he must have had a very low latent reservoir at that point, because 5 weeks later, he stopped all meds and remained in remission.
They give people with sickle cell anemia Hydroxyurea so maybe it is doable???
There is also Gemcitabine which induces lytic cycle.....cuz EBV can become resistant to Hydroxyurea.