Marco
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I thought this might be of interest given the prevalence of POTS and recent discussions about systemic mastocytosis and histamine :
Hyperadrenergic Postural Tachycardia Syndrome in Mast Cell Activation Disorders
Abstract
http://hyper.ahajournals.org/content/45/3/385.full
Hyperadrenergic Postural Tachycardia Syndrome in Mast Cell Activation Disorders
Abstract
Postural tachycardia syndrome (POTS) is a disabling condition that commonly affects otherwise normal young females. Because these patients can present with a flushing disorder, we hypothesized that mast cell activation (MCA) can contribute to its pathogenesis.
In conclusion, MCA should be considered in patients with POTS presenting with flushing. These patients often present with a typical hyperadrenergic response, but ?-blockers should be used with great caution, if at all, and treatment directed against mast cell mediators may be required.
http://hyper.ahajournals.org/content/45/3/385.full