nanonug
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Thanks to SOC for making me aware of the "newer" T helper 17 cells.
Th17 Cytokines and the Gut Mucosal Barrier
Th17 Cytokines and the Gut Mucosal Barrier
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I still can't figure out how I've managed to avoid the gut problems common in ME, especially given my very low IL-23 and low IL-17.
Indeed! Maybe you just happened to have the right kind of microbiota protecting you...
By the way, in case you didn't this question in the other thread, would you mind sharing the name of the test you did to find out about the Th17 stuff? Is that something you can order on the Internet? Thanks!
If so, I'm probably killing them off with long-term clarithromycin.
My immune testing was done at the University of Miami through Dr Rey. The page says "Cytokine Multiplex-18 Report" at the top. It could be specific to that lab. You might be able to find an immune test that includes IL-17 and IL-23 and maybe some other cytokines related to Th17. I think low cytotoxic T-cells may be related, too.
Indeed! Maybe you just happened to have the right kind of microbiota protecting you...
I don't think it's that easy. I never had yeast or pathogenic gut bacteria, I took tons of good probiotics, I have very high numbers of most good bacteria and still have these gut issues.
SIBO?
By the way, microbiota is composed of hundreds, maybe thousands of species acquired shortly after birth that in many cases assemble themselves in biofilms. These entities are then able to bidirectionally communicate with the host's immune system, sometimes for the best, sometimes for the worse. That's why I suggested that maybe SOC was just lucky with his microbiota. No amount of supplementation, is ever going to dramatically change this.
Perhaps at least we know the gut mucosal barrier/integrity has broken down so all GI research/understanding has to be a good thing for us. (possibly a role or more in many other diseases). Roll on this medical Cinderella - understanding the Gut and it's complex role as probably the most essential part of the immune system. Personally no doubts where ME all began whatever triggers.