Jemal
Senior Member
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This just popped up on the radar... full article is available as PDF. It's a NIH/FDA/HHS study.
http://www.virologyj.com/content/8/1/443/abstract
Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection.
Veerasamy Ravichandran, Eugen O Major, Carol Ibe, Maria Chiara Monaco, Mohan Kumar Haleyur Girisetty and Indira K Hewlett
Virology Journal 2011, 8:443 doi:10.1186/1743-422X-8-443
Published: 20 September 2011
Background
Xenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study, we investigated the susceptibility of primary neuronal cell types to infection with XMRV. Findings: We observed that the human primary progenitors, progenitor-derived neurons, and progenitor-derived astrocytes supported XMRV multiplication. Interestingly, both progenitors and progenitor-derived neurons were more susceptible compared with progenitor-derived astrocytes. In addition, XMRV-infected Jurkat cells were able to transmit infection to neuronal cells.
Conclusions
These data suggest that neuronal cells are susceptible for XMRV infection.
This study further substantiates our speculation that XMRV could infect brain cells. Further in-vitro and in-vivo studies are warranted to
identify and characterize the XMRV, and its role if any, in the brain cells.
http://www.virologyj.com/content/8/1/443/abstract