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Too much methylation. I'm dessesperate

Y

yellowspain

Messages
14
Hello. I have been poisoned by drinking sam-e. I think I've gone from being undermethylated to overmethylated. I'm scared because I have nutritional symptoms, there are days when I feel panic. In the blood tests I have had, my vitamin B12 is elevated (out of range) and my vitamin B9 is low, although within normal values. I don't know if this could be affecting me.

I would like to ask you for advice on supplements, I have read about niacin, has anyone tried it? Which niacin is better, the one that does not cause blushing or the normal one?

I would also like to know what tests I can undergo. Sam-e/sah's analysis is not available in my country. On the internet it says that histamine is a good indicator of methylation status. For those overmethylated, have you checked if your histamine is low? Thank you.
 
Judee

Judee

Psalm 46:1-3
Messages
4,497
Location
Great Lakes
Dr Ben Lynch recommends niacin for overmethylation. Not exactly your situation but maybe these links will give you some ideas.

https://mthfr.net/overmethylation-and-undermethylation-case-study/2012/06/27/

https://mthfr.net/taking-folate-and-feeling-badly-methylation-requires-balance/2011/11/15/

(I'm having one of my "can't read" times right now so I hopeful these will be helpful to you without steering you wrong. I see he does mention SAM-E in that first post.)

Also take the niacin low and slow. With that there's an uncomfortable flush that I can't handle...it makes it very difficult for me to breathe, so maybe research it to see if niacinamide would also work, if that's the case for you as well. ???

I think Chris Masterjohn also talks about overmethylation in his YT videos and recommends a different supplement as a remedy but I can't remember what that is right now. I'm sorry.

Hope your situation improves soon.
 
S

spoondragons

Messages
2
I was considering taking sam-e but i researched it and its not really a good idea because Sam-e is the end product of methylation. if you optimize your methylation you can produce more naturally, through folate and B12 supps... etc. taking sam-e is generally not recommended, because it can lead to serotonin syndrome especially if you're on antidepressants; https://www.verywellhealth.com/same-what-should-i-know-about-it-90004

or if you take supplements like st johns wort https://www.nccih.nih.gov/health/sadenosyllmethionine-same-in-depth

its also linked to one gene in the methylation cycle, COMT thats related to neurotransmitters, if you get the bad effects of it that could be why - the gene can be fast/slow https://theactionablehealth.substack.com/p/an-overview-of-slow-and-fast-comt

ive seen lots of anectodal stuff online about people not feeling great after taking sam-e too. could be a range of those reasons but it seems pretty unregulated. i think its best to just try and produce more naturally.
 
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