When something that worked excellently for 9 years suddenly doesn't , and it is in the most subtle place, the CNS, and suddenly hard CNS symptoms of a certain type hit hard, it isn't subjective is the sense of wondering if anything is even happening. That was clear. It was also clear what had happened. A bunch of people had already been asking about the change before I got clobbered. Then when all of us recovered that I know of by a change of brands, it's pretty well confirmed. So if you are asking what the confidence level is, it's 100% that something in the Jarrow MeCbl changed such that it was no longer CNS neurologically effective. And I did have startup all over again.
Thanks Freddd, then evidence is anecdotal although I have no doubt in this case if there was an appropriate test before and after some change would have been found. I just want to add that anecdotal doesn't imply any lesser of evidence especially when it involves larger number of people. And in fact IMO the internet has completely validated and improved substantially the value of anecdotal information by allowing collection places for first hand accounts such as this forum and allowing everyone to have a "global" voice. We all become part of an ongoing clinical study which is probably our best hope for having anything cured in the future since cures don't seem to be coming from anywhere else these days.
Now that zero doubt only belongs to people who interpret the startup of MeCbl as healing startup and adjust to the startup responses based on that theory. Then when healing has been going solidly for a month or five, when it suddenly turns off, it is very obvious. It makes it so each person can tell what works for them often within hours. One tries a different brand of MeCbl and healing stops and symptoms start coming back in 3 days or whatever. Same with various type of folate. If folic acid or folinic acid doesn't work for a person, whether alone or in combination, it becomes very obvious. One a person succeeds in turning healing on, they can stop guessing and hoping and believing. and floundering around. They can do a comparison, A-B, and know very quickly.
Are you referring to when the supps stop the ongoing stimulation of the Methylation cycle or a deeper action of the B12 you indicated in CNS healing?
I knew in less than an hour that the ENZY was massively superior to the Jarrow when I was in a position to try. When one has compared 20 or more brands it gets very easy. Normally I don't let myself get so debilitated all at once. When one is loosing neurological sensitivity all sorts of things fail to be noticed because of that very lack.
I trust what you say. I think you are the proverbial canary in the coal mine as far as B12 sensitivity goes from what I've been reading here.